Title:
CELL AGGREGATE, MIXTURE OF CELL AGGREGATES, AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2019/160148
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a cell aggregate containing dopamine-producing neural precursor cells suitable for transplantation; a mixture thereof; and a method for preparing the same. This cell aggregate contains FOXA2 positive nervous system cells or TUJ1 positive nervous system cells, and contains 1000 or more cells.
Inventors:
YOSHIDA KENJI (JP)
YOSHIKAWA MANABU (JP)
SEKIYA SAYAKA (JP)
YOSHIKAWA MANABU (JP)
SEKIYA SAYAKA (JP)
Application Number:
PCT/JP2019/005914
Publication Date:
August 22, 2019
Filing Date:
February 18, 2019
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
C12N5/0793; A61K35/30; A61L27/38; A61P9/10; A61P21/02; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P43/00; C12N5/074
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ANONYMOUS: "Concluded an exclusive product sales agency contract with US Site Nome", 6 September 2017 (2017-09-06), pages 1 - 2, XP055732207, Retrieved from the Internet [retrieved on 20190424]
KIMURA, TORU: "Development of iPS cell -derived nerve cell preparations used for functional regeneration therapy for Parkinson's disease", 2016-2017 BUSINESS REPORT OF FY2016-FY2017 EVALUATION BASIC TECHNOLOGY BUSINESS FOR INDUSTRIALIZATION OF REGENERATIVE MEDICINE (DEVELOPMENT OF EVALUATION METHODS FOR INDUSTRIALIZATION OF REGENERATIVE MEDICINE, ETC.), 21 December 2018 (2018-12-21), pages 1 - 44, XP009523530
WERNIG M ET AL., PROC NATL ACAD SCI U S A, vol. 105, 2008, pages 5856 - 5861
DOI D ET AL., STEM CELLS REPORTS, vol. 2, 2014, pages 337 - 350
SAMATA B ET AL., NATURE COMMUNICATION, vol. 7, 2016, pages 1 - 11
"NCBI", Database accession no. NM _ 001174147
CELLS, vol. 70, 1992, pages 841 - 847
OKITA, K. ET AL., STEM CELLS, vol. 31, 2013, pages 458 - 466
YAMANAKA ET AL., CELLS, vol. 126, no. 4, 2006, pages 663 - 676
CELLS, vol. 131, no. 5, 2007, pages 861 - 872
SCIENCE, vol. 318, no. 5858, 2007, pages 1917 - 1920
NAT. BIOTECHNOL., vol. 26, no. 1, 2008, pages 101 - 106
SCIENCE, vol. 341, 2013, pages 651 - 654
P. B. YU ET AL., CIRCULATION, vol. 116, no. II, 2007, pages 60
P.B. YU ET AL., NAT. CHEM. BIOL., vol. 4, 2008, pages 33 - 41
J. HAO ET AL., PLOS ONE, vol. 3, no. 8, 2008, pages e2904
R. K. LINDEMANN ET AL., MOL. CANCER, vol. 2, 2003, pages 20
MOL CANCER THER, vol. 3, 2004, pages 737 - 45
LI, X. ET AL., NATURE BIOTECHNOLOGY, vol. 23, 2005, pages 215 - 221
STANTON BZPENG LF., MOL BIOSYST, vol. 6, 2010, pages 44 - 54
"Genbank", Database accession no. NM _ 000193
NAT BIOTECHNOL, vol. 28, 2010, pages 611 - 615
EMBO J., vol. 3, 1984, pages 1463 - 1468
J. CELLS BIOL., vol. 105, 1987, pages 589 - 598
ISHIZAKI ET AL., MOL. PHARMACOL., vol. 57, 2000, pages 976 - 983
NARUMIYA ET AL., METHODS ENZYMOL, vol. 325, 2000, pages 273 - 284
UENATA ET AL., NATURE, vol. 389, 1997, pages 990 - 994
SASAKI ET AL., PHARMACOL. THER., vol. 93, 2002, pages 225 - 232
NAKAJIMA ET AL., CANCER CHEMOTHER PHARMACOL, vol. 52, no. 4, 2003, pages 319 - 324
NATURE METHODS, vol. 8, 2011, pages 424 - 429
PROC NATL ACAD SCI USA, vol. 105, no. 36, 9 September 2008 (2008-09-09), pages 13409 - 14
STEM CELLS REPORTS, vol. 2, 2014, pages 337 - 350
"Current protocols in Molecular Biology", 1987, JOHN WILEY AND SONS, pages: 11.12 - 11.11
ELLINGTON, A. D.SZOSTAK, J.W., NATURE, vol. 346, 1990, pages 818 - 822
TUERK, C.GOLD, L., SCIENCE, vol. 249, 1990, pages 505 - 510
HULSPAS R ET AL., CYTOTHERAPY, vol. 16, no. 10, October 2014 (2014-10-01), pages 1384 - 9
NATURE NEUROSCIENCE, vol. 2, 1999, pages 1137
N ENGL J MED, vol. 344, 2001, pages 710 - 9
MIYAZAKI T ET AL., NAT COMMUN, vol. 3, 2012, pages 1236
See also references of EP 3757208A4
KIMURA, TORU: "Development of iPS cell -derived nerve cell preparations used for functional regeneration therapy for Parkinson's disease", 2016-2017 BUSINESS REPORT OF FY2016-FY2017 EVALUATION BASIC TECHNOLOGY BUSINESS FOR INDUSTRIALIZATION OF REGENERATIVE MEDICINE (DEVELOPMENT OF EVALUATION METHODS FOR INDUSTRIALIZATION OF REGENERATIVE MEDICINE, ETC.), 21 December 2018 (2018-12-21), pages 1 - 44, XP009523530
WERNIG M ET AL., PROC NATL ACAD SCI U S A, vol. 105, 2008, pages 5856 - 5861
DOI D ET AL., STEM CELLS REPORTS, vol. 2, 2014, pages 337 - 350
SAMATA B ET AL., NATURE COMMUNICATION, vol. 7, 2016, pages 1 - 11
"NCBI", Database accession no. NM _ 001174147
CELLS, vol. 70, 1992, pages 841 - 847
OKITA, K. ET AL., STEM CELLS, vol. 31, 2013, pages 458 - 466
YAMANAKA ET AL., CELLS, vol. 126, no. 4, 2006, pages 663 - 676
CELLS, vol. 131, no. 5, 2007, pages 861 - 872
SCIENCE, vol. 318, no. 5858, 2007, pages 1917 - 1920
NAT. BIOTECHNOL., vol. 26, no. 1, 2008, pages 101 - 106
SCIENCE, vol. 341, 2013, pages 651 - 654
P. B. YU ET AL., CIRCULATION, vol. 116, no. II, 2007, pages 60
P.B. YU ET AL., NAT. CHEM. BIOL., vol. 4, 2008, pages 33 - 41
J. HAO ET AL., PLOS ONE, vol. 3, no. 8, 2008, pages e2904
R. K. LINDEMANN ET AL., MOL. CANCER, vol. 2, 2003, pages 20
MOL CANCER THER, vol. 3, 2004, pages 737 - 45
LI, X. ET AL., NATURE BIOTECHNOLOGY, vol. 23, 2005, pages 215 - 221
STANTON BZPENG LF., MOL BIOSYST, vol. 6, 2010, pages 44 - 54
"Genbank", Database accession no. NM _ 000193
NAT BIOTECHNOL, vol. 28, 2010, pages 611 - 615
EMBO J., vol. 3, 1984, pages 1463 - 1468
J. CELLS BIOL., vol. 105, 1987, pages 589 - 598
ISHIZAKI ET AL., MOL. PHARMACOL., vol. 57, 2000, pages 976 - 983
NARUMIYA ET AL., METHODS ENZYMOL, vol. 325, 2000, pages 273 - 284
UENATA ET AL., NATURE, vol. 389, 1997, pages 990 - 994
SASAKI ET AL., PHARMACOL. THER., vol. 93, 2002, pages 225 - 232
NAKAJIMA ET AL., CANCER CHEMOTHER PHARMACOL, vol. 52, no. 4, 2003, pages 319 - 324
NATURE METHODS, vol. 8, 2011, pages 424 - 429
PROC NATL ACAD SCI USA, vol. 105, no. 36, 9 September 2008 (2008-09-09), pages 13409 - 14
STEM CELLS REPORTS, vol. 2, 2014, pages 337 - 350
"Current protocols in Molecular Biology", 1987, JOHN WILEY AND SONS, pages: 11.12 - 11.11
ELLINGTON, A. D.SZOSTAK, J.W., NATURE, vol. 346, 1990, pages 818 - 822
TUERK, C.GOLD, L., SCIENCE, vol. 249, 1990, pages 505 - 510
HULSPAS R ET AL., CYTOTHERAPY, vol. 16, no. 10, October 2014 (2014-10-01), pages 1384 - 9
NATURE NEUROSCIENCE, vol. 2, 1999, pages 1137
N ENGL J MED, vol. 344, 2001, pages 710 - 9
MIYAZAKI T ET AL., NAT COMMUN, vol. 3, 2012, pages 1236
See also references of EP 3757208A4
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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