Title:
CELL CAPABLE OF EXPRESSING TSLP CONSTANTLY AND AT HIGH LEVEL, AND METHOD FOR SCREENING FOR TSLP MODULATOR UTILIZING THE CELL
Document Type and Number:
WIPO Patent Application WO/2012/001889
Kind Code:
A1
Abstract:
Disclosed is are: a mouse epithelial cell line capable of producing TSLP constantly; and use of the cell. More specifically disclosed are: a method for screening for a TSLP modulator using a mouse epithelial cell line (KCHM-1) that can produce TSLP constantly; and a process for producing natural TSLP using the cell line.
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Inventors:
HIRASAWA NORIYASU (JP)
HIDE MICHIHIRO (JP)
HIDE MICHIHIRO (JP)
Application Number:
PCT/JP2011/003329
Publication Date:
January 05, 2012
Filing Date:
June 13, 2011
Export Citation:
Assignee:
UNIV TOHOKU (JP)
HIRASAWA NORIYASU (JP)
HIDE MICHIHIRO (JP)
HIRASAWA NORIYASU (JP)
HIDE MICHIHIRO (JP)
International Classes:
C12P21/02; G01N33/53; C12Q1/02; G01N33/15; G01N33/50; C12R1/91
Foreign References:
| JP2009232812A | 2009-10-15 | |||
| JP2004519205A | 2004-07-02 | |||
| JP2009544302A | 2009-12-17 | |||
| JP2005516606A | 2005-06-09 | |||
| JP2007314547A | 2007-12-06 | |||
| JP2010096748A | 2010-04-30 |
Other References:
YOO J ET AL.: "Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin", J EXP MED, vol. 202, no. 4, 15 August 2005 (2005-08-15), pages 541 - 549
MORIMOTO K ET AL., THE EXTRACT OF SYNGENEIC KERATINOCYTES ENHANCES IGE PRODUCTION FROM BALB/C MOUSE SPLENIC LYMPHOCYTES IN VITRO, 2006
MORIMOTO K ET AL., THE EXTRACT OF SYNGENEIC KERATINOCYTES ENHANCES IGE PRODUCTION FROM BALB/C MOUSE SPLENIC LYMPHOCYTES IN VITRO, 2006
Attorney, Agent or Firm:
OHNO, Seiji et al. (JP)
Seiji Ono (JP)
Seiji Ono (JP)
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Claims: