Title:
CELL CYCLE PROGRESSION INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/167973
Kind Code:
A1
Abstract:
The present invention provides a cell cycle progression inhibitor, a cytostatic agent, and an anticancer agent. The cell cycle progression inhibitor, the cytostatic agent, and the anticancer agent each contains a Hes1 protein-PHB2 protein binding enhancer.
Inventors:
UESUGI MOTONARI (JP)
PERRON AMELIE (JP)
KODAMA YUZO (JP)
PERRON AMELIE (JP)
KODAMA YUZO (JP)
Application Number:
PCT/JP2019/007414
Publication Date:
September 06, 2019
Filing Date:
February 27, 2019
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
A61K45/06; A61K31/403
Domestic Patent References:
| WO1996031241A1 | 1996-10-10 |
Other References:
BAYTAS,S.N. ET AL.: "Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tublin polymerization inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22, no. 12, 2014, pages 3096 - 3104, XP028664746
UESUGI,M.: "Small molecules that control Hes1 oscillation", KAKEN.NII.AC.JP RESEARCH N°: 26560445, 31 March 2016 (2016-03-31), XP055635543, Retrieved from the Internet
KODAMA,Y.: "The role of Notch/Hesl signaling in the maintenance of homeostasis and carcinogenesis in pancreas", KAKEN.NII.AC.JP. RESEARCH N°: 25461022, 31 March 2016 (2016-03-31), XP055635550, Retrieved from the Internet
PERRON,A. ET AL.: "Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hesl via the PHB2 chaperone", J.JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 293, no. 21, 9 March 2018 (2018-03-09), pages 8285 - 8294, XP055635554
UESUGI,M.: "Small molecules that control Hes1 oscillation", KAKEN.NII.AC.JP RESEARCH N°: 26560445, 31 March 2016 (2016-03-31), XP055635543, Retrieved from the Internet
KODAMA,Y.: "The role of Notch/Hesl signaling in the maintenance of homeostasis and carcinogenesis in pancreas", KAKEN.NII.AC.JP. RESEARCH N°: 25461022, 31 March 2016 (2016-03-31), XP055635550, Retrieved from the Internet
PERRON,A. ET AL.: "Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hesl via the PHB2 chaperone", J.JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 293, no. 21, 9 March 2018 (2018-03-09), pages 8285 - 8294, XP055635554
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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