Title:
CELL CYCLE PROTEINS AND MITOSIS-ASSOCIATED MOLECULES
Document Type and Number:
WIPO Patent Application WO2002008255
Kind Code:
A3
Abstract:
The invention provides human cell cycle proteins and mitosis-associated molecules (CCMAM) and polynucleotides which identify and encode CCPMAM. The invention also provides methods for diagnosing, treating, or preventing disorders assocated with aberrant expression of CCPMAM.
Inventors:
BAUGHN MARIAH R (US)
LAL PREETI (US)
LU DYUNG AINA M (US)
NGUYEN DANNIEL B (US)
TRIBOULEY CATHERINE M (US)
YAO MONIQUE G (US)
YUE HENRY (US)
LAL PREETI (US)
LU DYUNG AINA M (US)
NGUYEN DANNIEL B (US)
TRIBOULEY CATHERINE M (US)
YAO MONIQUE G (US)
YUE HENRY (US)
Application Number:
PCT/US2001/022805
Publication Date:
November 28, 2002
Filing Date:
July 18, 2001
Export Citation:
Assignee:
INCYTE GENOMICS INC (US)
BAUGHN MARIAH R (US)
LAL PREETI (US)
LU DYUNG AINA M (US)
NGUYEN DANNIEL B (US)
TRIBOULEY CATHERINE M (US)
YAO MONIQUE G (US)
YUE HENRY (US)
BAUGHN MARIAH R (US)
LAL PREETI (US)
LU DYUNG AINA M (US)
NGUYEN DANNIEL B (US)
TRIBOULEY CATHERINE M (US)
YAO MONIQUE G (US)
YUE HENRY (US)
International Classes:
G01N33/50; A61K31/7088; A61K38/00; A61K45/00; A61K48/00; A61P1/00; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P5/00; A61P5/14; A61P7/00; A61P7/06; A61P7/08; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/02; A61P13/12; A61P15/00; A61P17/00; A61P17/02; A61P17/06; A61P19/00; A61P19/04; A61P19/10; A61P21/04; A61P25/02; A61P25/08; A61P25/14; A61P25/18; A61P25/28; A61P27/02; A61P27/06; A61P27/12; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P31/18; A61P33/02; A61P33/10; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/02; C12N15/09; C12N15/12; C12P21/02; C12P21/08; C12Q1/02; C12Q1/68; G01N33/15; G01N33/53; G01N33/566; (IPC1-7): C12N15/12; A61K38/17; A61K38/53; A61K39/00; C07K14/47; C07K16/18; C07K16/40; C12N5/10; C12N9/00; C12N15/52; C12Q1/68; G01N33/50; G01N33/53
Foreign References:
| US5976849A | 1999-11-02 | |||
| US6087122A | 2000-07-11 |
Other References:
DATABASE EMBL 16 December 1999 (1999-12-16), NATIONAL CANCER INSTITUTE: "te67e04.x1 Soares_NFL_T_GBC_S1 Homo sapiens cDNA clone (99.6 % identical in 751 nt overlap)", XP002190280
MITSUI K., NAKANISHI M., OHTSUKA S., NORWOOD T. OKABAYASHI K., MIYAMOTO C., TANAKA K., YOSHIMURA A., AND OHTSUBO M.: "A Novel Human Gene Encoding HECT Domain and RCC1-like Repeats Interacts with Cyclins and is Potentially Regulated by the Tumor Suppressor Proteins", BIOCHEM. BIOPH. RES. COMM., vol. 266, no. 1, 1999, pages 115-122, XP002190153
KUMAR S., HARVEY K., KINOSHITA M., COPELAND N.G., NODA M., AND JENKINS N.: "cDNA cloning, Expression Analysis, and Mapping of the Mouse Nedd4 Gene", GENOMICS, vol. 40, 1997, pages 435-443, XP002190152
SCHWARZ S.E., ROSA J., AND SCHEFFNER M.: "Characterization of Human HECT Domain Family Members and Their Interaction with UbcH5 and UbcH7", J. BIOL. CHEM., vol. 273, no. 20, May 1998 (1998-05-01), pages 12148-12154, XP002190154
HUIBREGTSE J M ET AL: "A FAMILY OF PROTEINS STRUCTURALLY AND FUNCTIONALLY RELATED TO THE E6-AP UBIQUITIN-PROTEIN LIGASE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 92, 28 March 1995 (1995-03-28), pages 2563 - 2567, XP000611567, ISSN: 0027-8424
PINES J ET AL: "ISOLATION OF A HUMAN CYCLIN CDNA: EVIDENCE FOR CYCLIN MRNA AND PROTEIN REGULATION IN THE CELL CYCLE AND FOR INTERACTION WITH P34CDC2", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 58, 1989, pages 833 - 846, XP000915698, ISSN: 0092-8674
MITSUI K., NAKANISHI M., OHTSUKA S., NORWOOD T. OKABAYASHI K., MIYAMOTO C., TANAKA K., YOSHIMURA A., AND OHTSUBO M.: "A Novel Human Gene Encoding HECT Domain and RCC1-like Repeats Interacts with Cyclins and is Potentially Regulated by the Tumor Suppressor Proteins", BIOCHEM. BIOPH. RES. COMM., vol. 266, no. 1, 1999, pages 115-122, XP002190153
KUMAR S., HARVEY K., KINOSHITA M., COPELAND N.G., NODA M., AND JENKINS N.: "cDNA cloning, Expression Analysis, and Mapping of the Mouse Nedd4 Gene", GENOMICS, vol. 40, 1997, pages 435-443, XP002190152
SCHWARZ S.E., ROSA J., AND SCHEFFNER M.: "Characterization of Human HECT Domain Family Members and Their Interaction with UbcH5 and UbcH7", J. BIOL. CHEM., vol. 273, no. 20, May 1998 (1998-05-01), pages 12148-12154, XP002190154
HUIBREGTSE J M ET AL: "A FAMILY OF PROTEINS STRUCTURALLY AND FUNCTIONALLY RELATED TO THE E6-AP UBIQUITIN-PROTEIN LIGASE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 92, 28 March 1995 (1995-03-28), pages 2563 - 2567, XP000611567, ISSN: 0027-8424
PINES J ET AL: "ISOLATION OF A HUMAN CYCLIN CDNA: EVIDENCE FOR CYCLIN MRNA AND PROTEIN REGULATION IN THE CELL CYCLE AND FOR INTERACTION WITH P34CDC2", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 58, 1989, pages 833 - 846, XP000915698, ISSN: 0092-8674
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