Title:
CELL DEATH SUPPRESSION AND TISSUE PROTECTION BY USE OF VOLATILIZED 2,2,6,6-TETRAMETHYL-1-PIPERIDINYLOXYL
Document Type and Number:
WIPO Patent Application WO/2022/071580
Kind Code:
A1
Abstract:
In the present invention, a low-molecular-weight compound 2,2,6,6-tetramtethyl-1-piperidinyloxyl (TEMPO) in the gas state is allowed to act on cells to suppress cell death associated with oxidative stress, thereby protecting tissue from tissue damage during the acute phase of ischemic disease.
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Inventors:
TORII SEIJI (JP)
KUBOTA CHISATO (JP)
KOSHIISHI ICHIRO (JP)
TAKIGAWA YUTA (JP)
MIZUNO HIROYUKI (JP)
SHINTOKU RYOSUKE (JP)
KUBOTA CHISATO (JP)
KOSHIISHI ICHIRO (JP)
TAKIGAWA YUTA (JP)
MIZUNO HIROYUKI (JP)
SHINTOKU RYOSUKE (JP)
Application Number:
PCT/JP2021/036440
Publication Date:
April 07, 2022
Filing Date:
October 01, 2021
Export Citation:
Assignee:
UNIV GUNMA NAT UNIV CORP (JP)
International Classes:
A61K31/445; A61K9/08; A61K9/20; A61K9/72; A61P9/10; A61P21/02; A61P25/00; A61P39/06; A61P43/00
Domestic Patent References:
| WO2009133647A1 | 2009-11-05 | |||
| WO2017051585A1 | 2017-03-30 |
Foreign References:
| JP2010520888A | 2010-06-17 |
Other References:
GRIESSER MARKUS, SHAH RON, VAN KESSEL ANTONIUS T., ZILKA OMKAR, HAIDASZ EVAN A., PRATT DEREK A.: "The Catalytic Reaction of Nitroxides with Peroxyl Radicals and Its Relevance to Their Cytoprotective Properties", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 140, no. 10, 14 March 2018 (2018-03-14), pages 3798 - 3808, XP055917913, ISSN: 0002-7863, DOI: 10.1021/jacs.8b00998
YUTA TAKIGAWA, SEIJI TORII, ICHIRO KOSHIISHI: "P-22 Evaluation of Effect of 1 Electric Redox in Ferroptosis-Inducing Cells", PROGRAM/ABSTRACTS OF THE 70TH MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH JAPAN; JUNE 28TH - 29TH, 2017, vol. 70, 28 June 2017 (2017-06-28) - 29 June 2017 (2017-06-29), JP, pages 142, XP009535686
HISAYUKI HOSOO, AIKI MARUSHIMA, YUKIO NAGASAKI, AKI HIRAYAMA, HIROMU ITO, SANDRA PUENTES, ARNELA MUJAGIC, HIDEO TSURUSHIMA,: "Neurovascular Unit Protection From Cerebral Ischemia-Reperfusion Injury by Radical-Containing Nanoparticles in Mice.", STROKE, vol. 48, no. 8, 1 August 2017 (2017-08-01), pages 2238 - 2247, XP055917916, DOI: 10.1161/STROKEAHA.116.016356
YUTA TAKIGAWA, SEIJI TORII, ICHIRO KOSHIISHI: "P-22 Evaluation of Effect of 1 Electric Redox in Ferroptosis-Inducing Cells", PROGRAM/ABSTRACTS OF THE 70TH MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH JAPAN; JUNE 28TH - 29TH, 2017, vol. 70, 28 June 2017 (2017-06-28) - 29 June 2017 (2017-06-29), JP, pages 142, XP009535686
HISAYUKI HOSOO, AIKI MARUSHIMA, YUKIO NAGASAKI, AKI HIRAYAMA, HIROMU ITO, SANDRA PUENTES, ARNELA MUJAGIC, HIDEO TSURUSHIMA,: "Neurovascular Unit Protection From Cerebral Ischemia-Reperfusion Injury by Radical-Containing Nanoparticles in Mice.", STROKE, vol. 48, no. 8, 1 August 2017 (2017-08-01), pages 2238 - 2247, XP055917916, DOI: 10.1161/STROKEAHA.116.016356
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
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