Title:
CELL DEVICE, METHOD FOR MANUFACTURING CELL DEVICE AND METHOD FOR IMPLANTING CELL DEVICE
Document Type and Number:
WIPO Patent Application WO/2020/105381
Kind Code:
A1
Abstract:
The present invention provides: a cell device that is capable of maintaining a cell aggregate at a high number density and achieving both a high therapeutic efficacy and a low invasiveness by means of the cell aggregate; a method for manufacturing the cell device; and a method for implanting the cell device. The cell device (1) used for cell transplantation is provided with: a carrier (20) for carrying a cell aggregate (10); and a case (30) for covering the carrier (20), wherein the carrier (20) has a porous substrate (21) and a cell adhesive layer (22) that is provided on the surface of the substrate (21) and composed of cell-adhesive molecules. The method for manufacturing the cell device comprises: a step for accommodating the carrier (20) in the case (30); and a step for introducing the cell aggregate (10) into pores of the carrier (20) by applying a coercive force. The method for implanting the cell device comprises a step for implanting the cell device (1), into which the cell coagulate (10) is introduced, in a living body other than a human.
Inventors:
MARUYAMA MASASHI (JP)
MATSUMORI MASAKI (JP)
SAKAI YASUYUKI (JP)
SHINOHARA MARIE (JP)
MATSUMORI MASAKI (JP)
SAKAI YASUYUKI (JP)
SHINOHARA MARIE (JP)
Application Number:
PCT/JP2019/042406
Publication Date:
May 28, 2020
Filing Date:
October 29, 2019
Export Citation:
Assignee:
HITACHI LTD (JP)
UNIV TOKYO (JP)
UNIV TOKYO (JP)
International Classes:
A61P3/10; A61K35/39; A61L27/18; A61L27/20; A61L27/22; A61L27/24; A61L27/38; A61L27/40; A61L27/50; A61L27/56; A61P5/50; A61P43/00; C12M1/00; C12M1/26; C12M3/00
Domestic Patent References:
| WO2016052504A1 | 2016-04-07 |
Foreign References:
| JP2016521614A | 2016-07-25 | |||
| JP2008278769A | 2008-11-20 | |||
| JP2003190259A | 2003-07-08 |
Other References:
SHINOHARA, MARIE ET AL.: "Regenerative medical techniques for diabetes mellitus", SEISAN KENKYU, vol. 68, no. 3, 2016, pages 189 - 194, XP055711074
KAWAZOE N ET AL.: "Three-dimensional cultures of rat pancreatic RIN-5F cells in porous PLGA-collagen hybrid scaffolds", JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, vol. 24, no. 1, 2009, pages 25 - 42, XP008166046, DOI: 10.1177/0883911508099439
PANG Y. ET AL.: "An insight into in vitro construction of implantable liver: from ''bottom up'' integrated with ''top down'' aspects", SEISAN-KENKYU, vol. 67, no. 3, 2015, pages 259 - 264, XP055711077
SAKAI, YASUYUKI ET AL: "II. Possible Contributions of Chemical Engineering to regenerative medicine: design,organization and rearing of artificial tissue", REGENERATIVE THERAPY, vol. 9, no. 3, 2010000, pages 361 - 366
KAWAZOE N ET AL.: "Three-dimensional cultures of rat pancreatic RIN-5F cells in porous PLGA-collagen hybrid scaffolds", JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, vol. 24, no. 1, 2009, pages 25 - 42, XP008166046, DOI: 10.1177/0883911508099439
PANG Y. ET AL.: "An insight into in vitro construction of implantable liver: from ''bottom up'' integrated with ''top down'' aspects", SEISAN-KENKYU, vol. 67, no. 3, 2015, pages 259 - 264, XP055711077
SAKAI, YASUYUKI ET AL: "II. Possible Contributions of Chemical Engineering to regenerative medicine: design,organization and rearing of artificial tissue", REGENERATIVE THERAPY, vol. 9, no. 3, 2010000, pages 361 - 366
Attorney, Agent or Firm:
ISONO INTERNATIONAL PATENT OFFICE, P.C. (JP)
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