Title:
CELL-DNA HYDROGEL COMPLEX AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2024/035104
Kind Code:
A1
Abstract:
The present invention relates to a cell-DNA hydrogel complex and a method for producing same. In the cell-DNA hydrogel complex of the present invention, cells with a first functional group protruding from the surface thereof and a DNA hydrogel into which a second functional group is introduced are linked via bonding, and thus, cell retention inside the cell-DNA hydrogel complex is excellent. The cell-DNA hydrogel complex of the present invention can promote the regeneration of damaged tissue by inducing cell migration and angiogenesis at a wound site. Details of the project that supported this invention are as follows. [Project identification number]1711149621[Project number]2021-RMD-S04[Ministry name]Ministry of Science and ICT[Project management (professional) organization name](Foundation)Commercializations Promotion Agency for R&D Outcomes[Research project name]Research material development·diffusion support (R&D)[Research project title]Development of biodegradable polymer-based bioplastic materials for research and development[Contribution rate]1/2[Name of organization carrying out project]University of Seoul[Research period]01 April 2021-31 December 2021 Details of another project that supported this invention are as follows. [Project identification number]1711158560[Project number]2022R1A2C2004820[Ministry name]Ministry of Science and ICT[Project management (professional) organization name]National Research Foundation of Korea[Research project name]Personal basic research (Ministry of Science and ICT)[Research project title]Development of rapid diagnosis platform for multi-variant RNA virus infection based on RdRP detection technology[Contribution rate]1/2[Name of organization carrying out project]University of Seoul[Research period]01 March 2022-28 February 2023
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Inventors:
LEE JONG BUM (KR)
NAM HYANG SU (KR)
NAM HYANG SU (KR)
Application Number:
PCT/KR2023/011733
Publication Date:
February 15, 2024
Filing Date:
August 09, 2023
Export Citation:
Assignee:
INSBIOPHARM CO LTD (KR)
International Classes:
A61L27/52; A61L27/36; A61L27/50; C12N5/00; C12N15/11
Foreign References:
| US20210130769A1 | 2021-05-06 | |||
| JP2020192021A | 2020-12-03 |
Other References:
KATRIN VOGEL, MAXIMILIAN GLETTENBERG, HENDRIK SCHROEDER, CHRISTOF M. NIEMEYER: "DNA-Modification of Eukaryotic Cells", SMALL, WILEY, vol. 9, no. 2, 28 January 2013 (2013-01-28), pages 255 - 262, XP055063367, ISSN: 16136810, DOI: 10.1002/smll.201201852
DESHPANDE SWAPNEEL R., HAMMINK ROEL, NELISSEN FRANK H. T., ROWAN ALAN E., HEUS HANS A.: "Biomimetic Stress Sensitive Hydrogel Controlled by DNA Nanoswitches", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 18, no. 10, 9 October 2017 (2017-10-09), US , pages 3310 - 3317, XP055785814, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b00964
DATABASE GEO 15 February 2020 (2020-02-15), ANONYMOUS : "HEK293_1kcells_KAS-IP.rep1 ", XP093137598, retrieved from NCBI Database accession no. GSM4141433
DESHPANDE SWAPNEEL R., HAMMINK ROEL, NELISSEN FRANK H. T., ROWAN ALAN E., HEUS HANS A.: "Biomimetic Stress Sensitive Hydrogel Controlled by DNA Nanoswitches", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 18, no. 10, 9 October 2017 (2017-10-09), US , pages 3310 - 3317, XP055785814, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b00964
DATABASE GEO 15 February 2020 (2020-02-15), ANONYMOUS : "HEK293_1kcells_KAS-IP.rep1 ", XP093137598, retrieved from NCBI Database accession no. GSM4141433
Attorney, Agent or Firm:
KIM, Hyun Jin (KR)
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