Title:
CELL-FREE DNA-BASED CANCER DIAGNOSIS MODEL AND USE
Document Type and Number:
WIPO Patent Application WO/2023/216469
Kind Code:
A1
Abstract:
Disclosed in the present invention are a cell-free DNA-based cancer diagnosis model and the use. In a first aspect of the present application, provided is a construction method of a cancer diagnosis model, the construction method comprising the following steps: acquiring sequencing data of cell-free DNAs of a non-cancer population; comparing the sequencing data of the cell-free DNAs with a reference genome to obtain corresponding sites of the tail ends of the cell-free DNAs on the reference genome; and constructing a cancer diagnosis model according to the corresponding sites of the tail ends of the cell-free DNAs on a target genome range. The present application uses an idea opposite to a mainstream method, and constructs a cancer diagnosis model by means of searching for a tail end distribution mode of cfDNAs of a non-cancer population, instead of attempting to identify a diagnosis marker based on a tumor cfDNA specific fragmentation mode. By means of the manner, patients with a plurality types of different cancers can be distinguished from a contrast population, achieving good specificity and sensitivity, and realizing pancancer type cancer diagnosis.
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Inventors:
SUN KUN (CN)
Application Number:
PCT/CN2022/116248
Publication Date:
November 16, 2023
Filing Date:
August 31, 2022
Export Citation:
Assignee:
SHENZHEN BAY LABORATORY (CN)
International Classes:
G16H50/20
Foreign References:
| CN110272985A | 2019-09-24 | |||
| CN113981081A | 2022-01-28 |
Attorney, Agent or Firm:
JIAQUAN IP LAW (CN)
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