Title:
CELL IMAGE EVALUATION DEVICE AND CELL IMAGE EVALUATION CONTROL PROGRAM
Document Type and Number:
WIPO Patent Application WO/2018/105432
Kind Code:
A1
Abstract:
Provided are a cell image evaluation device and a cell image evaluation program, whereby it becomes possible to ascertain the stained state of cells which would be expected if the cells are subjected to a staining treatment, without the need to carry out the staining treatment. The cell image evaluation device is provided with: an evaluation unit 21 for evaluating the state of cells contained in each of regions of interest in a cell image; and a prediction unit 22 in which a machine learning has been made in advance about the relation between evaluation results and the stained state of cells, wherein the evaluation results include both of the result of the evaluation of a specific region of interest in a first cell image obtained by imaging the cells before a staining treatment and the result of the evaluation of a region surrounding the specific region of interest in the first cell image, and the stained state of cells is the stained state of the cells in the specific region of interest in a second cell image obtained by imaging the same imaging target as that in the first cell image after the staining treatment of the cells. In the prediction unit 22, the stained state of cells in a specific region of interest is predicted on the basis of the result of the evaluation of a specific region of interest and the result of the evaluation of a region surrounding the specific region of interest, among the results of the evaluation of a third cell image of the cells before the staining treatment of the cells.
Inventors:
WAKUI TAKASHI (JP)
Application Number:
PCT/JP2017/042472
Publication Date:
June 14, 2018
Filing Date:
November 28, 2017
Export Citation:
Assignee:
FUJIFILM CORP (JP)
International Classes:
C12M1/34; G01N21/27; G01N33/48; G01N33/483; G06K9/00
Domestic Patent References:
| WO2015146064A1 | 2015-10-01 | |||
| WO2015182382A1 | 2015-12-03 | |||
| WO2011162213A1 | 2011-12-29 | |||
| WO2015025508A1 | 2015-02-26 |
Foreign References:
| US20140270457A1 | 2014-09-18 | |||
| JP2016509845A | 2016-04-04 | |||
| US20160035093A1 | 2016-02-04 | |||
| US20160253466A1 | 2016-09-01 | |||
| JP2011229409A | 2011-11-17 |
Other References:
WANG, M. ET AL.: "Novel cell segmentation and online SVM for cell cycle phase identification in automated microscopy", BIOINFORMATICS, vol. 24, 2008, pages 94 - 101, XP055510092
See also references of EP 3553165A4
See also references of EP 3553165A4
Attorney, Agent or Firm:
NAKASHIMA Junko et al. (JP)
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