Title:
CELL INJURY INDUCING THERAPEUTIC DRUG FOR USE IN CANCER THERAPY
Document Type and Number:
WIPO Patent Application WO/2017/159287
Kind Code:
A1
Abstract:
The present invention provides: an anticancer drug having, as an active ingredient, a bispecific antibody that contains, in a domain including an antibody variable region that binds to glypican-3 and a domain including an antibody variable region that binds to a T-cell receptor complex, a common L chain capable of improving affinity for both antigens; and a pharmaceutical composition that includes the bispecific antibody as an active ingredient and that is for concomitant use with another anticancer drug. The bispecific antibody is a novel and highly-safe molecule having high production efficiency, as well as strong antitumor activity and excellent pharmacokinetics, which is expected to be applied to various cancers.
Inventors:
KINOSHITA YASUKO (JP)
KAWAI YUMIKO (JP)
TSUNENARI TOSHIAKI (JP)
ISHIGURO TAKAHIRO (JP)
ENDO MIKA (JP)
SANO YUJI (JP)
KAWAI YUMIKO (JP)
TSUNENARI TOSHIAKI (JP)
ISHIGURO TAKAHIRO (JP)
ENDO MIKA (JP)
SANO YUJI (JP)
Application Number:
PCT/JP2017/007033
Publication Date:
September 21, 2017
Filing Date:
February 24, 2017
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K39/395; A61K45/00; A61P35/00; A61P43/00
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AITZIBER BUQUE ET AL.: "Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications", ONCOIMMUNOLOGY, vol. 4, no. 4, 2015, pages 1 - 16, XP055540479
NAT. BIOTECHNOL., vol. 23, 2005, pages 1073 - 1078
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SAMBROOK, J ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LAB. PRESS, pages: 9.47 - 9.58
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CELL, vol. 8, no. 3, 1976, pages 405 - 415
NATURE, vol. 276, no. 5685, 1978, pages 269 - 270
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SCIENCE, vol. 240, no. 4855, 1988, pages 1038 - 1041
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PROC. NATL. ACAD. SCI. U.S.A., vol. 85, no. 16, 1988, pages 5879 - 5883
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JOURNAL OF IMMUNOLOGY, vol. 152, no. 11, 1994, pages 5368 - 5374
PROTEIN ENGINEERING, vol. 9, no. 3, 1996, pages 299 - 305
PROC. NATL. ACAD. SCI. USA, vol. 103, no. 11, 2006, pages 4005 - 4010
DAVIS ET AL., IMMUNOLOGICAL REVIEWS, vol. 190, 2002, pages 123 - 136
PROC, NATL. ACAD. SCI. USA, vol. 103, no. 11, 2006, pages 4005 - 4010
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MILSTEIN ET AL., NATURE, vol. 305, 1983, pages 537 - 540
RIDGWAY JB, PROTEIN ENGINEERING, vol. 9, 1996, pages 617 - 621
MERCHANT A. M. ET AL., NATURE BIOTECHNOLOGY, vol. 16, 1998, pages 677 - 681
PROTEIN ENGINEERING DESIGN & SELECTION, vol. 23, 2010, pages 195 - 202
NAT BIOTECHNOL., vol. 32, no. 2, February 2014 (2014-02-01), pages 191 - 8
CHRISTOPH ET AL., NATURE BIOTECHNOLOGY, vol. 31, 2013, pages 753 - 758
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KRAMER W; FRITZ HJ: "Oligonucleotide-directed construction of mutations via gapped duplex DNA Methods", ENZYMOL, vol. 154, 1987, pages 350 - 367
KUNKEL, TA: "Rapid and efficient site-specific mutagenesis without phenotypic selection", PROC NATL ACAD SCI USA., vol. 82, 1985, pages 488 - 492, XP002052322, DOI: doi:10.1073/pnas.82.2.488
MARK, D. F. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 5662 - 6
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WANG, A. ET AL., SCIENCE, vol. 224, 1984, pages 1431 - 3
DALBADIE-MCFARLAND, G. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409 - 13
KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 7
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 10
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ZOLLER, M.J.; SMITH, M.: "Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors", METHODS ENZYMOL., vol. 100, 1983, pages 468 - 500, XP001088749, DOI: doi:10.1016/0076-6879(83)00074-9
KRAMER, W.; DRUTSA, V.; JANSEN, H.W.; KRAMER, B.; PFLUGFELDER, M.; FRITZ, H.J.: "The gapped duplex DNA approach to oligonucleotide-directed mutation construction", NUCLEIC ACIDS RES., vol. 12, 1984, pages 9441 - 9456, XP002026371
KRAMER, W.; FRITZ, H.J.: "Oligonucleotide-directed construction of mutations via gapped duplex DNA Methods", ENZYMOL, vol. 154, 1987, pages 350 - 367
KUNKEL, T.A.: "Rapid and efficient site-specific mutagenesis without phenotypic selection", PROC NATL ACAD. SCI. USA., vol. 82, 1985, pages 488 - 492, XP002052322, DOI: doi:10.1073/pnas.82.2.488
DALBA IE-MCFARLAND, G. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409 - 13
NAT. REV. IMMUNOL., vol. 12, 2012, pages 339 - 51
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 934823-49-1
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1393344-72-3
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1374853-91-4
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 946414-94-4
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1380723-44-3
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1537032-82-8
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1428935-60-7
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 477202-00-9
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HARUNA, Masao et al. (JP)
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