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Patent Searching and Data


Title:
CELL LABELING AGENT AND CELL LABELING KIT
Document Type and Number:
WIPO Patent Application WO/2019/151128
Kind Code:
A1
Abstract:
A cell labeling agent according to the present invention includes a monosaccharide derivative having a six-membered ring structure metabolized by sialic acid in a sialic acid biosynthesis pathway of a cell. Among groups bonded to carbon atoms constituting the six-membered ring in the monosaccharide derivative, at least one group which does not change even when metabolized by the sialic acid biosynthesis pathway includes a ring structure having a carbon-carbon double bond or triple bond.

Inventors:
XU YAN (JP)
ISHIZUKA TAKUMI (JP)
ZHAO PEI-YAN (JP)
Application Number:
PCT/JP2019/002440
Publication Date:
August 08, 2019
Filing Date:
January 25, 2019
Export Citation:
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Assignee:
UNIV MIYAZAKI (JP)
International Classes:
G01N33/48; C12Q1/02; G01N33/58; C07H7/027; C07H13/12
Foreign References:
JP2008515875A2008-05-15
JP2017505770A2017-02-23
JP2011504507A2011-02-10
JP2016506905A2016-03-07
US20130344527A12013-12-26
JP2013525425A2013-06-20
Other References:
AGARWAL PARESH ET AL.: "Systemic Fluorescence Imaging of Zebrafish Glycans with Bioorthogonal Chemistry", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 54, no. 39, 2015, pages 11504 - 11510, XP055628002
BATEMAN LESLIE ET AL.: "N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation", CHEMICAL COMMUNICATIONS, vol. 49, no. 39, 2013, pages 4328 - 4330, XP055628004
NING, X. ET AL.: "Visualizing metabolically labeled glycoconjugates of living cells by copper-free and fast huisgen cycloadditions", ANGEWANDTE CHEMIE, vol. 47, no. 12, 2008, pages 2253 - 2255, XP002659161
AGARD, N. J. ET AL.: "A Strain-Promoted [3+2] Azide-Alkyne Cycloaddition for Covalent Modification of Biomolecules in Livi", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, no. 46, 2004, pages 15046 - 15047, XP002362785, doi:10.1021/ja044996f
Attorney, Agent or Firm:
KIMURA Mitsuru (JP)
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