Title:
CELL LINE AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2004113511
Kind Code:
A3
Abstract:
The subject invention relates to a novel cell line, referred to as T42402I3.4.2, and to uses of this cell line. For example, the cell line may be used in the production of recombinant melanin concentrating hormone (MCH) receptor protein and in the identification of antagonists, inverse agonists and agonists to the receptor.
Inventors:
FRY DENNIS G (US)
COLLINS CHRISTINE A (US)
DAYTON BRIAN D (US)
COLLINS CHRISTINE A (US)
DAYTON BRIAN D (US)
Application Number:
PCT/US2004/018836
Publication Date:
April 28, 2005
Filing Date:
June 15, 2004
Export Citation:
Assignee:
ABBOTT LAB (US)
FRY DENNIS G (US)
COLLINS CHRISTINE A (US)
DAYTON BRIAN D (US)
FRY DENNIS G (US)
COLLINS CHRISTINE A (US)
DAYTON BRIAN D (US)
International Classes:
C07H21/04; C07K14/72; C12N5/06; C12N5/08; (IPC1-7): C12N5/08; C07K14/72
Other References:
DATABASE UniProt [online] 1 November 1997 (1997-11-01), "Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCHR-1) (MCH-R1) (MCH1R) (MCH-1R) (MCHR) (G protein coupled receptor 24) (Somatostatin receptor-like protein) (SLC-1).", XP002316310, retrieved from EBI accession no. UNIPROT:MCHR1_HUMAN Database accession no. MCHR1_HUMAN
TAKAHASHI K ET AL: "Expression of melanin-concentrating hormone receptor messenger ribonucleic acid in tumor tissues of pheochromocytoma, ganglioneuroblastoma, and neuroblastoma.", THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. JAN 2001, vol. 86, no. 1, January 2001 (2001-01-01), pages 369 - 374, XP002316309, ISSN: 0021-972X
TUMILOWICZ J J ET AL: "Definition of a continuous human cell line derived from neuroblastoma.", CANCER RESEARCH. AUG 1970, vol. 30, no. 8, August 1970 (1970-08-01), pages 2110 - 2118, XP009043570, ISSN: 0008-5472
ROSTOMILY R C ET AL: "Expression of neurogenic basic helix-loop-helix genes in primitive neuroectodermal tumors.", CANCER RESEARCH. 15 AUG 1997, vol. 57, no. 16, 15 August 1997 (1997-08-15), pages 3526 - 3531, XP001094111, ISSN: 0008-5472
SCHLUMBERGER SOPHIE E ET AL: "Endogenous receptor for melanin-concentrating hormone in human neuroblastoma Kelly cells.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 18 OCT 2002, vol. 298, no. 1, 18 October 2002 (2002-10-18), pages 54 - 59, XP002316415, ISSN: 0006-291X
TAKAHASHI K ET AL: "Expression of melanin-concentrating hormone receptor messenger ribonucleic acid in tumor tissues of pheochromocytoma, ganglioneuroblastoma, and neuroblastoma.", THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. JAN 2001, vol. 86, no. 1, January 2001 (2001-01-01), pages 369 - 374, XP002316309, ISSN: 0021-972X
TUMILOWICZ J J ET AL: "Definition of a continuous human cell line derived from neuroblastoma.", CANCER RESEARCH. AUG 1970, vol. 30, no. 8, August 1970 (1970-08-01), pages 2110 - 2118, XP009043570, ISSN: 0008-5472
ROSTOMILY R C ET AL: "Expression of neurogenic basic helix-loop-helix genes in primitive neuroectodermal tumors.", CANCER RESEARCH. 15 AUG 1997, vol. 57, no. 16, 15 August 1997 (1997-08-15), pages 3526 - 3531, XP001094111, ISSN: 0008-5472
SCHLUMBERGER SOPHIE E ET AL: "Endogenous receptor for melanin-concentrating hormone in human neuroblastoma Kelly cells.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 18 OCT 2002, vol. 298, no. 1, 18 October 2002 (2002-10-18), pages 54 - 59, XP002316415, ISSN: 0006-291X
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