Title:
CELL LINES FOR VIRUS PRODUCTION AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2014/123967
Kind Code:
A2
Abstract:
Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picomavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection.
Inventors:
KARPILOW JON MICHAEL (US)
OBERSTE MARK STEVEN (US)
TRIPP RALPH A (US)
TOMPKINS STEPHEN M (US)
OBERSTE MARK STEVEN (US)
TRIPP RALPH A (US)
TOMPKINS STEPHEN M (US)
Application Number:
PCT/US2014/014813
Publication Date:
August 14, 2014
Filing Date:
February 05, 2014
Export Citation:
Assignee:
UNIV GEORGIA (US)
US GOV HEALTH & HUMAN SERV (US)
THERMO FISHER SCIENT BIOSCIENCES INC (US)
US GOV HEALTH & HUMAN SERV (US)
THERMO FISHER SCIENT BIOSCIENCES INC (US)
International Classes:
C12N15/113
Foreign References:
| US8188060B2 | 2012-05-29 | |||
| US20090280567A1 | 2009-11-12 | |||
| GB240455A | 1926-12-16 |
Other References:
CARRINGTON ET AL., SCIENCE, vol. 301, 2003, pages 336 - 338
GRIFFITHS-JONES, NUCL. ACIDS RES., vol. 32, no. 1, 2004, pages D109 - D111
RAMOS, I, FRONT MICROBIOL, vol. 3, 2012, pages 117
KARLAS, A., NATURE, vol. 463, 2010, pages 818
KOLOKOLTSOV, J. VIROL., vol. 81, 2007, pages 7786
BRASS ET AL., SCIENCE, vol. 319, 2008, pages 921
KONIG ET AL., CELL, vol. 135, 2008, pages 49
SHANGARY, ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, vol. 49, 2009, pages 223
CRONICAN, J.J. ET AL., ACS CHEM. BIOL., vol. 5, no. 8, 2010, pages 747 - 52
HUTVAGNER ET AL., PLOS BIOL., vol. 2, 2004, pages E98
MEISTER ET AL., RNA, vol. 10, 2004, pages 544 - 550
VERMEULEN ET AL., RNA, vol. 13, 2007, pages 723 - 730
GIBSON ET AL., SCIENCE, vol. 329, 2010, pages 52 - 56
ZHANG ET AL., J. BIOMOL SCREEN, vol. 4, no. 2, 1999, pages 67 - 73
KARBER G: "Beitrag zur kollektiven behandlung pharmakologischer reihenversuche", ARCHIV FIIR EXPERIMENTALISCHE PATHOLOGIE UND PHARMAKOLOGIE, vol. 162, 1931, pages 480 - 483
KÄRBER G: "Beitrag zur kollektiven behandlung pharmakologischer reihenversuche", ARCHIV FUR EXPERIMENTALISCHE PATHOLOGIE UND PHARMAKOLOGIE, vol. 162, 1931, pages 480 - 483
KARBER G: "Beitrag zur kollektiven behandlung pharmakologischer reihenversuche", ARCHIV FUR EXPERIMENTALISCHE PATHOLOGIE UND PHARMAKOLOGIE, vol. 162, 1931, pages 480 - 483
GRIFFITHS-JONES, NUCL. ACIDS RES., vol. 32, no. 1, 2004, pages D109 - D111
RAMOS, I, FRONT MICROBIOL, vol. 3, 2012, pages 117
KARLAS, A., NATURE, vol. 463, 2010, pages 818
KOLOKOLTSOV, J. VIROL., vol. 81, 2007, pages 7786
BRASS ET AL., SCIENCE, vol. 319, 2008, pages 921
KONIG ET AL., CELL, vol. 135, 2008, pages 49
SHANGARY, ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, vol. 49, 2009, pages 223
CRONICAN, J.J. ET AL., ACS CHEM. BIOL., vol. 5, no. 8, 2010, pages 747 - 52
HUTVAGNER ET AL., PLOS BIOL., vol. 2, 2004, pages E98
MEISTER ET AL., RNA, vol. 10, 2004, pages 544 - 550
VERMEULEN ET AL., RNA, vol. 13, 2007, pages 723 - 730
GIBSON ET AL., SCIENCE, vol. 329, 2010, pages 52 - 56
ZHANG ET AL., J. BIOMOL SCREEN, vol. 4, no. 2, 1999, pages 67 - 73
KARBER G: "Beitrag zur kollektiven behandlung pharmakologischer reihenversuche", ARCHIV FIIR EXPERIMENTALISCHE PATHOLOGIE UND PHARMAKOLOGIE, vol. 162, 1931, pages 480 - 483
KÄRBER G: "Beitrag zur kollektiven behandlung pharmakologischer reihenversuche", ARCHIV FUR EXPERIMENTALISCHE PATHOLOGIE UND PHARMAKOLOGIE, vol. 162, 1931, pages 480 - 483
KARBER G: "Beitrag zur kollektiven behandlung pharmakologischer reihenversuche", ARCHIV FUR EXPERIMENTALISCHE PATHOLOGIE UND PHARMAKOLOGIE, vol. 162, 1931, pages 480 - 483
Attorney, Agent or Firm:
PROVENCE, David, L. (P.A.PO Box 58133, Minneapolis MN, US)
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