Title:
CELL MODEL FOR NEOVASCULAR DISEASES USING EBV-INFECTED HUMAN RETINAL PIGMENT EPITHELIAL CELLS
Document Type and Number:
WIPO Patent Application WO/2014/098314
Kind Code:
A1
Abstract:
The present invention relates to a cell model for neovascular diseases using Epstein Barr virus (EBV)-infected human retinal pigment epithelial (ARPE) cells. Provided is a method for preparing a cell model for neovascular diseases, comprising the steps of: infecting cells with EBV; culturing the infected cells; and checking whether the cultured cells are infected with the EBV. Provided also is a cell model for neovascular diseases prepared by said preparation method. Further, provided is a method for screening neovascular disease therapeutic agents using the cell model for neovascular diseases.
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Inventors:
HUR DAE YOUNG (KR)
PARK GA BIN (KR)
KIM YEONG SEOK (KR)
KIM SEONG HAN (KR)
LEE HYUN KYUNG (KR)
KIM KYEONG HWAN (KR)
YANG JAE WOOK (KR)
KIM DAE JIN (KR)
PARK GA BIN (KR)
KIM YEONG SEOK (KR)
KIM SEONG HAN (KR)
LEE HYUN KYUNG (KR)
KIM KYEONG HWAN (KR)
YANG JAE WOOK (KR)
KIM DAE JIN (KR)
Application Number:
PCT/KR2013/001335
Publication Date:
June 26, 2014
Filing Date:
February 20, 2013
Export Citation:
Assignee:
UNIV INJE IND ACAD COOPERATION (KR)
International Classes:
C12N5/071; G01N33/15; G01N33/68
Domestic Patent References:
| WO2000052158A1 | 2000-09-08 |
Other References:
TSANG, CHI MAN ET AL.: "Epstein-Barr virus infection in immortalized nasopharyngeal epithelial cells: regulation of infection and phenotypic characterization", INTERNATIONAL JOURNAL OF CANCER, vol. 127, no. 7, 20 January 2010 (2010-01-20), pages 1570 - 1383
HAU, POK MAN ET AL.: "Idl interacts and stabilizes the epstein-barr virus latent membrane protein 1 (LMPl) in nasopharyngeal epithelial cells", PLOS ONE, vol. 6, no. 6, 20 June 2011 (2011-06-20), pages E21176
SHANNON-LOWE. CLAIRE ET AL.: "Features distinguishing epstein-barr virus infections of epithelial cells and B Cells: viral genome expression, genome maintenance, and genome amplification", JOURNAL OF VIROLOGY, vol. 83, no. 15, 13 May 2009 (2009-05-13), pages 7749 - 7760
MA, SHI-DONG ET AL.: "A new model of epstein-barr virus infection reveals an important role for early lytic viral protein expression in the development of lymphomas", JOURNAL OF VIROLOGY, vol. 85, no. 1, 27 October 2010 (2010-10-27), pages 165 - 177
HAU, POK MAN ET AL.: "Idl interacts and stabilizes the epstein-barr virus latent membrane protein 1 (LMPl) in nasopharyngeal epithelial cells", PLOS ONE, vol. 6, no. 6, 20 June 2011 (2011-06-20), pages E21176
SHANNON-LOWE. CLAIRE ET AL.: "Features distinguishing epstein-barr virus infections of epithelial cells and B Cells: viral genome expression, genome maintenance, and genome amplification", JOURNAL OF VIROLOGY, vol. 83, no. 15, 13 May 2009 (2009-05-13), pages 7749 - 7760
MA, SHI-DONG ET AL.: "A new model of epstein-barr virus infection reveals an important role for early lytic viral protein expression in the development of lymphomas", JOURNAL OF VIROLOGY, vol. 85, no. 1, 27 October 2010 (2010-10-27), pages 165 - 177
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
특허법인 태백 (KR)
특허법인 태백 (KR)
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