Title:
CELL PERMEABLE INHIBITORS OF ANAPHASE PROMOTING COMPLEX
Document Type and Number:
WIPO Patent Application WO/2012/031118
Kind Code:
A3
Abstract:
The invention provides compositions and methods for treating cell cycle disorders. Compositions of the invention include proTAME, a prodrug analog of TAME, and, optionally, one or more therapeutic agents.
Inventors:
KING RANDALL (US)
ZENG XING (US)
ZENG XING (US)
Application Number:
PCT/US2011/050203
Publication Date:
July 19, 2012
Filing Date:
September 01, 2011
Export Citation:
Assignee:
HARVARD COLLEGE (US)
KING RANDALL (US)
ZENG XING (US)
KING RANDALL (US)
ZENG XING (US)
International Classes:
A61K31/155; A61K31/198; A61K31/337; A61K31/63; A61P35/00
Foreign References:
| US6951730B2 | 2005-10-04 |
Other References:
JOHN F. DISTEFANO ET AL.: "Pharmacological Studies of the Mechanism of Tumor -induced Bone Marrow Cytolysis.", CANCER RESEARCH, vol. 39, no. 4, April 1979 (1979-04-01), pages 1193 - 1198
V. EISEN: "Effect of hxadimethrine bromide on plasma kinin formation, hydroly sis of p-tosyl-l-arginine methyl ester and fibrinolysis.", BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY., vol. 22, February 1964 (1964-02-01), pages 87 - 103
F. FIEDLER ET AL.: "Activation, Inhibition, and pH-Dependence of the Hydroly sis of alpha-N-Benzoyl-L-arginine Ethyl Ester CAtalyzed by Kallikrein from P orcine Pancreas.", EUROPEAN JOURNAL OF BIOCHEMISTRY., vol. 7, no. 1, December 1968 (1968-12-01), pages 7 - 33
V. EISEN: "Effect of hxadimethrine bromide on plasma kinin formation, hydroly sis of p-tosyl-l-arginine methyl ester and fibrinolysis.", BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY., vol. 22, February 1964 (1964-02-01), pages 87 - 103
F. FIEDLER ET AL.: "Activation, Inhibition, and pH-Dependence of the Hydroly sis of alpha-N-Benzoyl-L-arginine Ethyl Ester CAtalyzed by Kallikrein from P orcine Pancreas.", EUROPEAN JOURNAL OF BIOCHEMISTRY., vol. 7, no. 1, December 1968 (1968-12-01), pages 7 - 33
Attorney, Agent or Firm:
BEATTIE, Ingrid, A. et al. (P.C.One Financial Cente, Boston MA, US)
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