CELL POPULATION INCLUDING ATTACHED CELLS DERIVED FROM FETAL APPENDAGES, PRODUCTION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION

Title:

CELL POPULATION INCLUDING ATTACHED CELLS DERIVED FROM FETAL APPENDAGES, PRODUCTION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION

Document Type and Number:

WIPO Patent Application WO/2018/186418

Kind Code:

A1

Abstract:

The present invention addresses the problem of providing a cell population which includes attached cells derived from fetal appendages and has a low differentiation potential, a production method therefor, and a pharmaceutical composition which includes the cell population. The present invention provides a production method for a cell population which includes attached cells derived from fetal appendages, wherein the production method involves obtaining a cell population having the following cell characteristics indicated in (a) and (b): (a) the ratio of attached cells derived from fetal appendages which are positive for CD73 and CD90 in the cell population is 90% or higher; and (b) the cell population satisfies the condition that the relative expression level of the LFA-3 gene to the expression level of the SDHA gene is 1.0 or higher.

Inventors:

INO KEITA (JP)
KITA YUTA (JP)

Application Number:

PCT/JP2018/014323

Publication Date:

October 11, 2018

Filing Date:

April 03, 2018

Export Citation:

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Assignee:

KANEKA CORP (JP)

International Classes:

C12N5/071; A61K35/12; A61K35/50; A61L27/38; A61P1/04; A61P1/16; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00

Domestic Patent References:

WO2017073656A1	2017-05-04
WO2018092769A1	2018-05-24
WO2013077428A1	2013-05-30

Foreign References:

JP2015061520A	2015-04-02
US20130108589A1	2013-05-02
JP2015061520A	2015-04-02

Other References:

WEGMEYER, HEIKE ET AL.: "Mesenchymal Stromal Cell Characteristics Vary Depending on Their Origin", STEM CELLS AND DEVELOPMENT, vol. 22, no. 19, 15 May 2013 (2013-05-15), pages 2606 - 2618, XP055558274
ONKEN JE ET AL., AMERICAN COLLEGE OF GASTROENTEROLOGY CONFERENCE, 2006
GARCIA-OLMO D ET AL., DIS COLON RECTUM, vol. 48, 2005, pages 1416 - 23
See also references of EP 3608399A4

Attorney, Agent or Firm:

SIKS & CO. (JP)

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