Title:
CELL POPULATION INCLUDING MESENCHYMAL STEM CELLS, PRODUCTION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2018/186421
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a cell population which includes mesenchymal cells showing low cell aggregation and is useful for the intravenous administration of a cell preparation, a production method therefor, and a pharmaceutical composition which includes the cell population. The present invention provides a production method for a cell population which includes mesenchymal stem cells, wherein the production method involves obtaining a cell population having given cell characteristics (the cell population satisfies the conditions that the relative expression level of the COL11A1 gene to the expression level of the SDHA gene is 6.0 or lower, and that the relative expression level of the COL16A1 gene to the expression level of the SDHA gene is 1.5 or lower).
Inventors:
INO KEITA (JP)
KITA YUTA (JP)
KITA YUTA (JP)
Application Number:
PCT/JP2018/014326
Publication Date:
October 11, 2018
Filing Date:
April 03, 2018
Export Citation:
Assignee:
KANEKA CORP (JP)
International Classes:
C12N5/0775; A61K35/28; A61P1/04; A61P1/16; A61P3/10; A61P9/04; A61P9/10; A61P11/00; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/04; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08
Domestic Patent References:
| WO2013077428A1 | 2013-05-30 | |||
| WO2011043136A1 | 2011-04-14 |
Foreign References:
| JP2015500810A | 2015-01-08 | |||
| JP2008178403A | 2008-08-07 | |||
| JP2010538681A | 2010-12-16 | |||
| JP2010500047A | 2010-01-07 | |||
| JP2015061520A | 2015-04-02 | |||
| JP2010500047A | 2010-01-07 | |||
| JP2013256510A | 2013-12-26 |
Other References:
NEJADNIK, HOSSEIN ET AL.: "Improved Approach for Chondrogenic Differentiation of Human Induced Pluripotent Stem Cells", STEM CELL REV AND REP, vol. 11, 2015, pages 242 - 253, XP035485517
WEGMEYER, HEIKE ET AL.: "Mesenchymal Stromal Cell Characteristics Vary Depending on Their Origin", STEM CELLS AND DEVELOPMENT, vol. 22, no. 19, 2013, pages 2606 - 2618, XP055557848
ONKEN JE ET AL.: "American College of Gastroenterology Conference", 2006
GARCIA-OLMO D ET AL., DIS COLON RECTUM, vol. 48, 2005, pages 1416 - 23
See also references of EP 3608400A4
WEGMEYER, HEIKE ET AL.: "Mesenchymal Stromal Cell Characteristics Vary Depending on Their Origin", STEM CELLS AND DEVELOPMENT, vol. 22, no. 19, 2013, pages 2606 - 2618, XP055557848
ONKEN JE ET AL.: "American College of Gastroenterology Conference", 2006
GARCIA-OLMO D ET AL., DIS COLON RECTUM, vol. 48, 2005, pages 1416 - 23
See also references of EP 3608400A4
Attorney, Agent or Firm:
SIKS & CO. (JP)
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