Title:
CELL REPROGRAMMING COMPOSITION COMPRISING REX1 AND AN INDUCED PLURIPOTENT STEM CELL PRODUCTION METHOD USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2012/096552
Kind Code:
A3
Abstract:
The present invention relates to a reprogramming inducing composition comprising the Rex1 protein or a nucleic acid molecule coding for the Rex1 protein for producing induced pluripotent stem cells from body cells or non-embryonic cells through a reprogramming process. The present invention also relates to a method for producing induced pluripotent stem cells by using the Rex1.
Inventors:
CHO YEE SOOK (KR)
SON MI YOUNG (KR)
SON MI YOUNG (KR)
Application Number:
PCT/KR2012/000363
Publication Date:
October 04, 2012
Filing Date:
January 16, 2012
Export Citation:
Assignee:
KOREA RES INST OF BIOSCIENCE (KR)
CHO YEE SOOK (KR)
SON MI YOUNG (KR)
CHO YEE SOOK (KR)
SON MI YOUNG (KR)
International Classes:
C12N5/074; C12N5/02; C12N5/10; C12N15/12; C12N15/63
Other References:
TAKAHASHI ET AL.: "Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors", CELL, vol. 126, 25 August 2006 (2006-08-25), pages 663 - 676
NERI ET AL.: "Mouse fibroblasts are reprogrammed to Oct-4 and Rex-1 gene expression and alkaline phosphatase activity by embryonic stem cell extracts", CLONING AND STEM CELLS, vol. 9, no. 3, 2007, pages 394 - 406, XP002483807, DOI: doi:10.1089/clo.2006.0011
CAI ET AL.: "Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 15, 9 April 2010 (2010-04-09), pages 11227 - 11234
NERI ET AL.: "Mouse fibroblasts are reprogrammed to Oct-4 and Rex-1 gene expression and alkaline phosphatase activity by embryonic stem cell extracts", CLONING AND STEM CELLS, vol. 9, no. 3, 2007, pages 394 - 406, XP002483807, DOI: doi:10.1089/clo.2006.0011
CAI ET AL.: "Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 15, 9 April 2010 (2010-04-09), pages 11227 - 11234
Attorney, Agent or Firm:
SON, Min (6th Floor, City Air Tower,36, Teheran-ro 87 gil, Samsung-don, Gangnam-gu Seoul 135-973, KR)
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