Title:
CELL FOR USE IN IMMUNOTHERAPY WHICH CONTAINS MODIFIED NUCLEIC ACID CONSTRUCT ENCODING WILMS TUMOR GENE PRODUCT OR FRAGMENT THEREOF, METHOD FOR PRODUCING SAID CELL, AND SAID NUCLEIC ACID CONSTRUCT
Document Type and Number:
WIPO Patent Application WO/2013/018778
Kind Code:
A1
Abstract:
A cell according to the present invention is a cell containing a nucleic acid construct encoding a WT1 gene product or a fragment thereof, wherein the nucleic acid construct contains a region encoding a desired fragment of the WT1 gene product and also contains only AUG as a functional initiation codon. The present invention can provide a cell into which a nucleic acid construct having a significantly improved level of expression of a WT1 gene product or a fragment thereof is introduced.
Inventors:
FUJII SHIN-ICHIRO (JP)
SHIMIZU KANAKO (JP)
SHINGA JUN (JP)
SHIMIZU KANAKO (JP)
SHINGA JUN (JP)
Application Number:
PCT/JP2012/069377
Publication Date:
February 07, 2013
Filing Date:
July 30, 2012
Export Citation:
Assignee:
RIKEN (JP)
FUJII SHIN-ICHIRO (JP)
SHIMIZU KANAKO (JP)
SHINGA JUN (JP)
FUJII SHIN-ICHIRO (JP)
SHIMIZU KANAKO (JP)
SHINGA JUN (JP)
International Classes:
C12N15/09; A61K39/00; C12N5/10; C07K14/82
Domestic Patent References:
| WO2007119564A1 | 2007-10-25 | |||
| WO2011059835A2 | 2011-05-19 | |||
| WO2007097370A1 | 2007-08-30 | |||
| WO2010061930A1 | 2010-06-03 | |||
| WO2007097370A1 | 2007-08-30 | |||
| WO2010061930A1 | 2010-06-03 | |||
| WO2005045027A1 | 2005-05-19 | |||
| WO2005053618A2 | 2005-06-16 | |||
| WO2007016466A2 | 2007-02-08 |
Foreign References:
| US20030072767A1 | 2003-04-17 | |||
| EP2308987A2 | 2011-04-13 | |||
| EP1127068A1 | 2001-08-29 |
Other References:
SHASTRI N. ET AL.: "Major histocompatibility class I molecules can present cryptic translation products to T-cells", J. BIOL. CHEM., vol. 270, no. 3, 20 January 1995 (1995-01-20), pages 1088 - 1091, XP000891819
NAT. IMMUNOL., vol. 3, 2002, pages 867 - 874
J. IMMUNOL. METH., vol. 272, 2003, pages 147 - 159
J. EXP. MED., vol. 198, 2003, pages 267 - 279
J. EXP. MED., vol. 199, 2004, pages 1607 - 1618
J. IMMUNOL., vol. 167, 2001, pages 3114 - 3122
INT. J. CANCER, vol. 109, 2004, pages 402 - 11
J. IMMUNOL., vol. 171, 2003, pages 5140 - 5147
J. CLIN. INVEST., vol. 114, 2004, pages 1800 - 11
J. EXP. MED., vol. 184, 1996, pages 465 - 472
NAT. MED., vol. 2, 1996, pages 1122 - 1128
NAT. MED., vol. 6, 2000, pages 1011 - 1017
J. CLIN. INVEST., vol. 109, 2002, pages 409 - 417
J. IMMUNOL., vol. 174, 2005, pages 3798 - 3807
BR. J. CANCER, vol. 93, 2005, pages 749 - 756
CANCER GENE THER., vol. 13, 2006, pages 905 - 918
See also references of EP 2738253A4
NAT. IMMUNOL., vol. 3, 2002, pages 867 - 874
J. IMMUNOL. METH., vol. 272, 2003, pages 147 - 159
J. EXP. MED., vol. 198, 2003, pages 267 - 279
J. EXP. MED., vol. 199, 2004, pages 1607 - 1618
J. IMMUNOL., vol. 167, 2001, pages 3114 - 3122
INT. J. CANCER, vol. 109, 2004, pages 402 - 11
J. IMMUNOL., vol. 171, 2003, pages 5140 - 5147
J. CLIN. INVEST., vol. 114, 2004, pages 1800 - 11
J. EXP. MED., vol. 184, 1996, pages 465 - 472
NAT. MED., vol. 2, 1996, pages 1122 - 1128
NAT. MED., vol. 6, 2000, pages 1011 - 1017
J. CLIN. INVEST., vol. 109, 2002, pages 409 - 417
J. IMMUNOL., vol. 174, 2005, pages 3798 - 3807
BR. J. CANCER, vol. 93, 2005, pages 749 - 756
CANCER GENE THER., vol. 13, 2006, pages 905 - 918
See also references of EP 2738253A4
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (JP)
Patent business corporation Hara [Kenzo] international patent firm (JP)
Patent business corporation Hara [Kenzo] international patent firm (JP)
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