Title:
CELLS CAPABLE OF DIFFERENTIATING INTO HEART MUSCLE CELLS
Document Type and Number:
WIPO Patent Application WO/2001/048151
Kind Code:
A1
Abstract:
Methods of isolating, purifying, culturing and differentiation-inducing cells which are capable of differentiating into heart muscle cells; a method of proliferating cells which are capable of differentiating into heart muscle cells and a method of regulating the differentiation thereof into heart muscle cells by using various cytokines, transcriptional factors, etc.; a method of acquiring a surface antigen specific to cells which are capable of differentiating into heart muscle cells; a method of acquiring a gene encoding this surface antigen; a method of acquiring an antibody specific to the above surface antigen; a method of acquiring a protein and a gene participating in the proliferation of cells which are capable of differentiating into heart muscle cells and differentiation thereof into heart muscle cells; remedies for various heart diseases with the use of cells which are capable of differentiating into heart muscle cells; and a method of inducing the differentiation of various cells (nerve cells, liver cells, fat cells, skeletal muscle cells, vascular endothelial cells, osteoblasts, etc.) and tissues by using cells which are capable of differentiating into heart muscle cells.
Inventors:
UMEZAWA AKIHIRO
HATA JUN-ICHI
FUKUDA KEIICHI
OGAWA SATOSHI
SAKURADA KAZUHIRO
GOJO SATOSHI
YAMADA YOJI
HATA JUN-ICHI
FUKUDA KEIICHI
OGAWA SATOSHI
SAKURADA KAZUHIRO
GOJO SATOSHI
YAMADA YOJI
Application Number:
PCT/JP2000/009323
Publication Date:
July 05, 2001
Filing Date:
December 27, 2000
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
International Classes:
A61K33/44; A61K35/28; A61K38/18; A61P9/04; A61P9/06; C07K16/28; C12N5/071; C12N5/077; C12N5/0789; C12N15/12; C12P21/08; C12Q1/02; A61K35/12; (IPC1-7): C12N5/06; C12N5/08; C12P21/08; C12Q1/02; A61K35/28; A61K33/44; A61P9/06; A61P9/04
Other References:
MAKINO S. ET AL.: "Cardiomyocytes can be generated from marrow stromal cells in vitro", J. CLIN. INVEST., vol. 103, no. 5, March 1999 (1999-03-01), pages 697 - 705, XP002938938
KEICHI FUKUDA: "Kotsuzui saibou kara no shinkin saibou no yuudo", HUMAN CELL, vol. 12, no. 3, September 1999 (1999-09-01), pages 159 - 162, XP002938939
GUAN K. ET AL.: "Embryonic stem cell differentiation models: cardiogenesis, myogenesis, neurogensis, epithelial and vascular smooth muscle cell", CYTOTECHNOLOGY, vol. 30, no. 1-3, May 1999 (1999-05-01), pages 211 - 226, XP002938940
KOLOSSOV, E. ET AL.: "Functional characteristics of ES cell-derived cardiac precursor cells identified by tissue-specific expression of the green fluorescent", J. CELL BIOL., vol. 143, no. 7, 1998, pages 2045 - 2056, XP002938941
XIAOXIA G. ET AL.: "Properties and applications of embryonic stem cells", CHINESE SCIENE BULLETIN, vol. 45, no. 14, July 2000 (2000-07-01), pages 1258 - 1265, XP002938942
See also references of EP 1254952A4
KEICHI FUKUDA: "Kotsuzui saibou kara no shinkin saibou no yuudo", HUMAN CELL, vol. 12, no. 3, September 1999 (1999-09-01), pages 159 - 162, XP002938939
GUAN K. ET AL.: "Embryonic stem cell differentiation models: cardiogenesis, myogenesis, neurogensis, epithelial and vascular smooth muscle cell", CYTOTECHNOLOGY, vol. 30, no. 1-3, May 1999 (1999-05-01), pages 211 - 226, XP002938940
KOLOSSOV, E. ET AL.: "Functional characteristics of ES cell-derived cardiac precursor cells identified by tissue-specific expression of the green fluorescent", J. CELL BIOL., vol. 143, no. 7, 1998, pages 2045 - 2056, XP002938941
XIAOXIA G. ET AL.: "Properties and applications of embryonic stem cells", CHINESE SCIENE BULLETIN, vol. 45, no. 14, July 2000 (2000-07-01), pages 1258 - 1265, XP002938942
See also references of EP 1254952A4
Download PDF:
Previous Patent: ADULT BONE MARROW-ORIGIN CELL CAPABLE OF DIFFERENTIATING INTO HEART MUSCLE CELL
Next Patent: TISSUE ENGINEERING USING MANDIBULAR CELLS
Next Patent: TISSUE ENGINEERING USING MANDIBULAR CELLS