Title:
CELLS EXPRESSING PRE-PRO-PRECURSOR FORM CHIMERIC ANTIGEN RECEPTOR TARGETING IGF1R
Document Type and Number:
WIPO Patent Application WO/2023/145961
Kind Code:
A1
Abstract:
Provided is an IGF1R CAR-T cell that is expected to be effective against tumors that express IGF1R. Provided is a polynucleotide that encodes a chimeric antigen receptor (CAR) protein having a target-binding domain that binds to the insulin-like growth factor-1 receptor (IGF1R), a transmembrane domain, and an intracellular signaling domain, wherein the target-binding domain is the pre-pro-precursor for insulin-like growth factor (IGF) or its E-domain-deleted fragment. Also provided are a vector containing this polynucleotide and genetically modified cells into which this polypeptide or vector has been introduced.
Inventors:
NAKAZAWA YOZO (JP)
HIRABAYASHI KOICHI (JP)
MARUYAMA YUTA (JP)
YAGYU SHIGEKI (JP)
MISHIMA SHUJI (JP)
SHIMIZU KIMIHIRO (JP)
HIRABAYASHI KOICHI (JP)
MARUYAMA YUTA (JP)
YAGYU SHIGEKI (JP)
MISHIMA SHUJI (JP)
SHIMIZU KIMIHIRO (JP)
Application Number:
PCT/JP2023/003012
Publication Date:
August 03, 2023
Filing Date:
January 31, 2023
Export Citation:
Assignee:
UNIV SHINSHU (JP)
International Classes:
C12N15/62; A61K35/17; A61P35/00; A61P35/02; C12M1/00; C12M3/00; C12N5/0783; C12N5/10; C12N15/12; C12N15/63; C07K14/65; C07K14/725; C07K19/00
Domestic Patent References:
| WO2019090215A2 | 2019-05-09 |
Foreign References:
| JP2021512911A | 2021-05-20 | |||
| JP2009542719A | 2009-12-03 | |||
| JP2009539383A | 2009-11-19 |
Other References:
XIN HUANG, PARK HAEIN, GREENE JOSEPH, PAO JAMES, MULVEY ERIN, ZHOU SOPHIA, ALBERT CATHERINE, MOY FRED, SACHDEV DEEPALI, YEE DOUGLA: "IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for High Risk Sarcomas", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, vol. 10, no. 7, pages e0133152, XP055339394, DOI: 10.1371/journal.pone.0133152
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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