Title:
CELLULAR CONSTITUENTS FROM BACTEROIDES, COMPOSITIONS THEREOF, AND THERAPEUTIC METHODS EMPLOYING BACTEROIDES OR CELLULAR CONSTITUENTS THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/153226
Kind Code:
A3
Abstract:
A cellular constituent is lysed from, produced by and/or isolated from one or more bacteria from the genus Bacteroides, and the cellular constituent, a derivative thereof, and/or one or more bacteria from the genus Bacteroides, or a modified form thereof, is employed in compositions and methods for modulating an inflammatory response. Such methods include methods of treating, delaying the onset of, or reducing the symptoms of one or more inflammatory conditions/diseases, including corporal or gastrointestinal inflammation, for example, Irritable Bowel Syndrome, Crohn's Disease, or colitis, and/or associated diseases such diabetes, asthma, multiple sclerosis, cancer, rheumatoid arthritis, gingivitis, atopic diseases, for example, hay fever, food allergies, eczema, rhinitis, dermatitis, conjunctivitis, atopic syndrome and keratosis pelaris, ocular inflammatory disease, strokes, cardiovascular disease, depression, atherosclerosis and hypertension, and comprise administering a composition comprising one or more natural and/or modified bacteria of the genus Bacteroides, and/or a cellular constituent lysed from, produced by, or isolated from one or more natural and/or modified bacteria from the genus Bacteroides, or a derivative thereof.
Inventors:
MOORE BRENDA E (US)
Application Number:
PCT/US2011/038742
Publication Date:
March 08, 2012
Filing Date:
June 01, 2011
Export Citation:
Assignee:
MOORE RES ENTPR LLC (US)
MOORE BRENDA E (US)
MOORE BRENDA E (US)
International Classes:
C12N1/20; A61K35/66; A61K35/74; A61P3/10; A61P9/00; A61P35/00; C12N1/06
Other References:
WEXLER, H. M.: "Bacteroides: the good, the bad, and the nitty-gritty", CLIN. MICROBIOL. REV., vol. 20, no. 4, October 2007 (2007-10-01), pages 593 - 621
MAZMANIAN, S. K. ET AL.: "A microbial symbiosis factor prevents intestinal in flammatory disease", NATURE, vol. 453, 29 May 2008 (2008-05-29), pages 620 - 625
TROY, E. B. ET AL.: "Beneficial effects of Bacteroides fragilis polysaccharides on the immune system", FRONT BIOSCI., vol. 15, 1 January 2010 (2010-01-01), pages 25 - 34
HOOPER, L. V. ET AL.: "Angiogenins: a new class of microbicidal proteins involved in innate immunity", NAT. IMMUNOL., vol. 4, no. 3, March 2003 (2003-03-01), pages 269 - 273
See also references of EP 2585583A4
MAZMANIAN, S. K. ET AL.: "A microbial symbiosis factor prevents intestinal in flammatory disease", NATURE, vol. 453, 29 May 2008 (2008-05-29), pages 620 - 625
TROY, E. B. ET AL.: "Beneficial effects of Bacteroides fragilis polysaccharides on the immune system", FRONT BIOSCI., vol. 15, 1 January 2010 (2010-01-01), pages 25 - 34
HOOPER, L. V. ET AL.: "Angiogenins: a new class of microbicidal proteins involved in innate immunity", NAT. IMMUNOL., vol. 4, no. 3, March 2003 (2003-03-01), pages 269 - 273
See also references of EP 2585583A4
Attorney, Agent or Firm:
KOZLOWSKI, Holly, D. et al. (41 South High Street Columbus, OH, US)
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