Title:
CEPHALOSPORIN COMPOUNDS, USE THEREOF AND INTERMEDIATE COMPOUNDS OF THE SAME
Document Type and Number:
WIPO Patent Application WO/1998/058933
Kind Code:
A1
Abstract:
Cephalosporin compounds (I) represented by general formula (I) or pharmaceutically acceptable salts thereof: wherein R?1¿ represents hydrogen or an amino-protective group; R?2¿ represents hydrogen, lower alkyl or a hydroxy-protective group; R?3¿ represents optionally esterified carboxy; and R?4¿ represents optionally substituted thiazolyl. These compounds (I) or their pharmaceutically acceptable salts are excellent in absorbability via the digestive tracts when administered orally and have a sufficient antimicrobial activity over a broad range of bacteria, which makes them highly useful as preventives and remedies for infectious diseases (in particular, microbisms).
Inventors:
KASAI MASAYASU (JP)
HATANO SATORU (JP)
NISHIMURA KEN-ICHI (JP)
KAKEYA NOBUHARU (JP)
HATANO SATORU (JP)
NISHIMURA KEN-ICHI (JP)
KAKEYA NOBUHARU (JP)
Application Number:
PCT/JP1998/002714
Publication Date:
December 30, 1998
Filing Date:
June 17, 1998
Export Citation:
Assignee:
KYOTO PHARMA IND (JP)
KASAI MASAYASU (JP)
HATANO SATORU (JP)
NISHIMURA KEN ICHI (JP)
KAKEYA NOBUHARU (JP)
KASAI MASAYASU (JP)
HATANO SATORU (JP)
NISHIMURA KEN ICHI (JP)
KAKEYA NOBUHARU (JP)
International Classes:
A61K31/545; A61K31/546; A61P31/04; C07D501/00; C07D501/59; (IPC1-7): C07D501/59; A61K31/545
Foreign References:
| EP0268307A2 | 1988-05-25 | |||
| JPH08259572A | 1996-10-08 | |||
| JPS6236385A | 1987-02-17 |
Attorney, Agent or Firm:
Takashima, Hajime (3-9 Hiranomachi 3-chome, Chuo-k, Osaka-shi Osaka, JP)
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