Title:
CEPHALOSPORIN DERIVATIVES, PROCESS AND THEIR PREPARATION, AND PROPHYLACTIC AND TREATING AGENT AGAINST BACTERIAL INFECTION
Document Type and Number:
WIPO Patent Application WO/1984/001949
Kind Code:
A1
Abstract:
Cephalosporin derivatives represented by the general formula (I), wherein R1 represents an alpha-, beta- or gamma-amino acid residue (bonded through an ester bond) whose amino group is optionally susbstituted by a lower alkyl group, R2 represents a l-alkanoyl-oxyalkyl group, a l-alkoxycarbonyloxyalkyl group, a phthalidyl group or a 5-methyl-1, 3-dioxolen-2-on-4-ylmethyl group, R3 represents a carbamoyloxymethyl group optionally substituted by a lower alkyl group, or a heterocyclic thiomethyl group optionally substituted by a suitable substituent, and R4 represents a hydrogen atom or a hydroxy group, and non-toxic salts thereof are rapidly absorbed in blood by oral administration to exhibit an excellent antibacterial effect, thus useful as an oral prophylactic and treating agent against bacterial infection.
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Inventors:
KAKEYA NOBUHARU (JP)
NISHIZAWA SUSUMU (JP)
TAMAKI SATOSHI (JP)
KITAO KAZUHIKO (JP)
NISHIZAWA SUSUMU (JP)
TAMAKI SATOSHI (JP)
KITAO KAZUHIKO (JP)
Application Number:
PCT/JP1982/000437
Publication Date:
May 24, 1984
Filing Date:
November 10, 1982
Export Citation:
Assignee:
KYOTO PHARMA IND (JP)
International Classes:
A61K31/545; A61K31/546; A61P31/04; C07D501/36; B60J10/08; C07D501/04; C07D501/24; C07D501/32; C07D501/34; C07D501/44; C07D501/46; C07D501/54; A61K; C07D; (IPC1-7): C07D501/32; C07D501/36; A61K31/545
Foreign References:
| JPS4711273A | ||||
| JPS4712579A | ||||
| JPS50121294A | 1975-09-23 | |||
| JPS5116688A | 1976-02-10 | |||
| JPS5283877A | 1977-07-13 | |||
| US4172196A | 1979-10-23 |
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