Title:
CERAMIDE ANIONIC LIPOSOME COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO/2012/154942
Kind Code:
A3
Abstract:
Described herein are pharmaceutical compositions according to aspects of the present invention which include one or more hydrophilic antineoplastic chemotherapeutics, such as vinca alkyloid antineoplastic chemotherapeutics, encapsulated in ceramide anionic liposomes. Methods of treatment of a subject having cancer using the pharmaceutical compositions are described, along with methods of making ceramide anionic liposomes which encapsulate one or more hydrophilic antineoplastic chemotherapeutics in the aqueous interior of the ceramide anionic liposomes.
Inventors:
KESTER MARK (US)
SHANMUGAVELANDY SRIRAM S (US)
FOX TODD (US)
SHANMUGAVELANDY SRIRAM S (US)
FOX TODD (US)
Application Number:
PCT/US2012/037295
Publication Date:
January 03, 2013
Filing Date:
May 10, 2012
Export Citation:
Assignee:
PENN STATE RES FOUND (US)
KESTER MARK (US)
SHANMUGAVELANDY SRIRAM S (US)
FOX TODD (US)
KESTER MARK (US)
SHANMUGAVELANDY SRIRAM S (US)
FOX TODD (US)
International Classes:
A61K9/127; A61K31/475; A61K47/30; A61P35/00
Domestic Patent References:
| WO1999030686A1 | 1999-06-24 |
Foreign References:
| US20070116753A1 | 2007-05-24 | |||
| US20070031480A1 | 2007-02-08 | |||
| US20040253302A1 | 2004-12-16 | |||
| US20070003607A1 | 2007-01-04 | |||
| US20110229529A1 | 2011-09-22 |
Other References:
M. A. TRAN ET AL.: "Combining nanoliposomal ceramide with sorafenib synergistically inhibits melanoma and breast cancer cell survival to decrease tumor development", CLINICAL CANCER RESEARCH, vol. 14, no. 11, 1 June 2008 (2008-06-01), pages 3571 - 3581, XP055142613
D. C. DRUMMOND ET AL.: "Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors", PHARMACOLOGICAL REVIEWS, vol. 51, no. 4, 1999, pages 691 - 743, XP009059957
N. MAURER ET AL.: "Developments in liposomal drug delivery systems", EXPERT OPINION ON BIOLOGICAL THERAPY, vol. 1, no. 6, 2001, pages 1 - 25, XP055142616
D. C. DRUMMOND ET AL.: "Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors", PHARMACOLOGICAL REVIEWS, vol. 51, no. 4, 1999, pages 691 - 743, XP009059957
N. MAURER ET AL.: "Developments in liposomal drug delivery systems", EXPERT OPINION ON BIOLOGICAL THERAPY, vol. 1, no. 6, 2001, pages 1 - 25, XP055142616
Attorney, Agent or Firm:
STAPLE, Julie, K. et al. (Krass Sprinkle, Anderson & Citkowski, P.C.,2701 Troy Center Drive, Suite 330, Po Box 702, Troy MI, US)
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