Title:
CERAMIDE CONTENT INCREASING AGENTS
Document Type and Number:
WIPO Patent Application WO/2017/122495
Kind Code:
A1
Abstract:
A ceramidase inhibitor which comprises a compound represented by formula (I) or a pharmaceutically acceptable salt thereof; and a ceramide synthesis promoter which comprises a compound represented by formula (II) or a pharmaceutically acceptable salt thereof. The ceramidase inhibitor and ceramide synthesis promoter according to the present invention can increase the amount of ceramide in cells or skin and, therefore, are appropriately usable for, e.g., moisturizing, reducing wrinkles, ameliorating atopic dermatitis symptoms, preventing/treating xeroderma, preventing spots, tightening flabby skin, anti-itching, suppressing melanogenesis, enhancing barrier function, activating fibroblasts and regenerating skin cells.
Inventors:
KATO ATSUSHI
ISHIKAWA FUMIHIRO
MIURA DAISUKE
ISHIKAWA FUMIHIRO
MIURA DAISUKE
Application Number:
PCT/JP2016/087537
Publication Date:
July 20, 2017
Filing Date:
December 16, 2016
Export Citation:
Assignee:
NAT UNIV CORP UNIV OF TOYAMA (JP)
FUSHIMI PHARMACEUTICAL CO LTD (JP)
FUSHIMI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K31/351; A61K8/60; A61K31/366; A61K31/70; A61K31/7004; A61K31/7012; A61K31/7024; A61K31/7028; A61P17/00; A61P37/08; A61P43/00; A61Q1/00; A61Q5/00; A61Q19/00; C07D309/10; C07H15/18
Domestic Patent References:
| WO2014171279A1 | 2014-10-23 | |||
| WO1999047541A1 | 1999-09-23 | |||
| WO2015154074A1 | 2015-10-08 |
Foreign References:
| JP2011006341A | 2011-01-13 | |||
| JPH11255656A | 1999-09-21 | |||
| JPH07242526A | 1995-09-19 | |||
| JP2004517109A | 2004-06-10 | |||
| JP2014088329A | 2014-05-15 |
Other References:
LEE, YOUN-SUN. ET AL.: "Protective effect of ginsenoside Rg1 on H2O2-induced cell death by the decreased ceramide level in LLC- PK 1 cells", JOURNAL OF GINSENG RESEARCH, 2006, pages 30
KAMORI, A. ET AL.: "Dual action of acertannins as potential regulators of intracellular ceramide levels", TETRAHEDRON : ASYMMETRY, vol. 27, no. 22, 12 October 2016 (2016-10-12), pages 1177 - 1185, XP029789149, DOI: 10.1016/j.tetasy.2016.09.006
KAMORI, A. ET AL.: "Dual action of acertannins as potential regulators of intracellular ceramide levels", TETRAHEDRON : ASYMMETRY, vol. 27, no. 22, 12 October 2016 (2016-10-12), pages 1177 - 1185, XP029789149, DOI: 10.1016/j.tetasy.2016.09.006
Attorney, Agent or Firm:
HOSODA, Yoshinori (JP)
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