Title:
CERAMIDE AND SPHINGOMYELIN IN NEUROLOGICAL DISORDERS
Document Type and Number:
WIPO Patent Application WO/2022/226427
Kind Code:
A3
Abstract:
Lipids, including sphingomyelins (SMs), have been shown to be disrupted in Alzheimer's disease (AD). The impacts of lipid alterations on AD pathogenesis are not fully understood. What is needed are methods for assessing and modulating the levels of novel biological targets, such as ceramide and sphingomyelin, in neurological disorders such as AD, Parkinson's Disease, and multiple sclerosis. Described herein are compositions and methods for assessing and modulating ceramide and sphingomyelin in neurological disorders.
Inventors:
LOUIE GREGORY (US)
ARNOLD MATTHIAS (DE)
BAILLE REBECCA (US)
MEIKLE PETER (AU)
HAN XIANLIN (US)
SAYKIN ANDREW (US)
NHO NHO KWANGSIK (US)
MORENO HERMAN (US)
ARNOLD MATTHIAS (DE)
BAILLE REBECCA (US)
MEIKLE PETER (AU)
HAN XIANLIN (US)
SAYKIN ANDREW (US)
NHO NHO KWANGSIK (US)
MORENO HERMAN (US)
Application Number:
PCT/US2022/026231
Publication Date:
January 26, 2023
Filing Date:
April 25, 2022
Export Citation:
Assignee:
UNIV DUKE (US)
METABOLOMICS LABORATORY (AU)
METABOLOMICS LABORATORY BAKER HEART & DIABETES INST (AU)
UNIV OF TX HEALTH CENTER AT SAN ANTONIO (US)
UNIV OF TEXAS HEALTH CENTER AT SAN ANTONIO (US)
INDIANA UNIV (US)
INDIANA ALZHEIMER DISEASE CENTER AND DEPT OF RADIOLOGY AND IMAGING SCIENCES (US)
SUNY DOWNSTATE MEDICAL CENTER (US)
INST SYSTEMS BIOLOGY (US)
INST OF COMPUTATIONAL BIOLOGY (DE)
HELMHOLTZ ZENTRUM MUNCHEN GERMAN RES CENTER FOR ENVIRONMENTAL HEALTH (DE)
KADDURAH DAOUK RIMA (US)
LOUIE GREGORY (US)
ARNOLD MATTHIAS (DE)
BAILLE REBECCA (US)
MEIKLE PETER (AU)
HAN XIANLIN (US)
SAYKIN ANDREW (US)
NHO NHO KWANGSIK (US)
MORENO HERMAN W (US)
FUNK CORY (US)
BALONI PRIYANKA (US)
KASTENMUELLER GABI (DE)
METABOLOMICS LABORATORY (AU)
METABOLOMICS LABORATORY BAKER HEART & DIABETES INST (AU)
UNIV OF TX HEALTH CENTER AT SAN ANTONIO (US)
UNIV OF TEXAS HEALTH CENTER AT SAN ANTONIO (US)
INDIANA UNIV (US)
INDIANA ALZHEIMER DISEASE CENTER AND DEPT OF RADIOLOGY AND IMAGING SCIENCES (US)
SUNY DOWNSTATE MEDICAL CENTER (US)
INST SYSTEMS BIOLOGY (US)
INST OF COMPUTATIONAL BIOLOGY (DE)
HELMHOLTZ ZENTRUM MUNCHEN GERMAN RES CENTER FOR ENVIRONMENTAL HEALTH (DE)
KADDURAH DAOUK RIMA (US)
LOUIE GREGORY (US)
ARNOLD MATTHIAS (DE)
BAILLE REBECCA (US)
MEIKLE PETER (AU)
HAN XIANLIN (US)
SAYKIN ANDREW (US)
NHO NHO KWANGSIK (US)
MORENO HERMAN W (US)
FUNK CORY (US)
BALONI PRIYANKA (US)
KASTENMUELLER GABI (DE)
International Classes:
C12Q1/68; A61K31/164; A61P25/28; G01N33/92
Domestic Patent References:
| WO2018049268A1 | 2018-03-15 | |||
| WO2022081350A2 | 2022-04-21 |
Foreign References:
| US20090029473A1 | 2009-01-29 | |||
| US20080096845A1 | 2008-04-24 |
Other References:
YAGI TSUKASA, KUSCHNER CYRUS E., SHOAIB MUHAMMAD, CHOUDHARY RISHABH C., BECKER LANCE B., LEE ANNETTE T., KIM JUNHWAN: "Relative Ratios Enhance the Diagnostic Power of Phospholipids in Distinguishing Benign and Cancerous Ovarian Masses", CANCERS, vol. 12, no. 1, 26 December 2019 (2019-12-26), pages 72, XP093027854, DOI: 10.3390/cancers12010072
BLASCO H., VEYRAT-DUREBEX C., BOCCA C., PATIN F., VOURC’H P., KOUASSI NZOUGHET J., LENAERS G., ANDRES C. R., SIMARD G., CORCIA P.,: "Lipidomics Reveals Cerebrospinal-Fluid Signatures of ALS", SCIENTIFIC REPORTS, vol. 7, no. 1, XP093027853, DOI: 10.1038/s41598-017-17389-9
LI JUAN, XIE LI-MIN, SONG JIN-LONG, YAU LEE-FONG, MI JIA-NING, ZHANG CHUN-REN, WU WAN-TING, LAI MAO-HUA, JIANG ZHI-HONG, WANG JING: "Alterations of Sphingolipid Metabolism in Different Types of Polycystic Ovary Syndrome", SCIENTIFIC REPORTS, vol. 9, no. 1, XP093027852, DOI: 10.1038/s41598-019-38944-6
BALONI PRIYANKA, ARNOLD MATTHIAS, BUITRAGO LUNA, NHO KWANGSIK, MORENO HERMAN, HUYNH KEVIN, BRAUNER BARBARA, LOUIE GREGORY, KUEIDER: "Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease", COMMUNICATIONS BIOLOGY, vol. 5, no. 1, XP093027850, DOI: 10.1038/s42003-022-04011-6
BLASCO H., VEYRAT-DUREBEX C., BOCCA C., PATIN F., VOURC’H P., KOUASSI NZOUGHET J., LENAERS G., ANDRES C. R., SIMARD G., CORCIA P.,: "Lipidomics Reveals Cerebrospinal-Fluid Signatures of ALS", SCIENTIFIC REPORTS, vol. 7, no. 1, XP093027853, DOI: 10.1038/s41598-017-17389-9
LI JUAN, XIE LI-MIN, SONG JIN-LONG, YAU LEE-FONG, MI JIA-NING, ZHANG CHUN-REN, WU WAN-TING, LAI MAO-HUA, JIANG ZHI-HONG, WANG JING: "Alterations of Sphingolipid Metabolism in Different Types of Polycystic Ovary Syndrome", SCIENTIFIC REPORTS, vol. 9, no. 1, XP093027852, DOI: 10.1038/s41598-019-38944-6
BALONI PRIYANKA, ARNOLD MATTHIAS, BUITRAGO LUNA, NHO KWANGSIK, MORENO HERMAN, HUYNH KEVIN, BRAUNER BARBARA, LOUIE GREGORY, KUEIDER: "Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease", COMMUNICATIONS BIOLOGY, vol. 5, no. 1, XP093027850, DOI: 10.1038/s42003-022-04011-6
Attorney, Agent or Firm:
HARTWIG, Gregory, J. et al. (US)
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