Title:
CERASOME DELIVERY SYSTEM FOR USE IN TARGETED ACTIVATION OF CD44 MOLECULE, PREPARATION METHOD THEREFOR AND USE
Document Type and Number:
WIPO Patent Application WO/2018/188635
Kind Code:
A1
Abstract:
A cerasome delivery system for use in the targeted activation of a CD44 molecule, a preparation method and use thereof: a surface of a cerasome is partially modified by a targeting ligand, the targeting ligand being a ligand which may specifically bind to an activated CD44 molecule. The cerasome delivery system may be used for the diagnosis, prevention and treatment of vulnerable plaque or diseases associated with vulnerable plaque.
Inventors:
MA QIAN (CN)
SUN JIEFANG (CN)
SUN JIEFANG (CN)
Application Number:
PCT/CN2018/082850
Publication Date:
October 18, 2018
Filing Date:
April 12, 2018
Export Citation:
Assignee:
BEIJING INNO MEDICINE CO LTD (CN)
International Classes:
A61P7/00; A61K9/127; A61P9/00
Foreign References:
| CN105708800A | 2016-06-29 | |||
| CN106177982A | 2016-12-07 |
Other References:
KOLODGIE ET AL.: "Differential Accumulation of Proteoglycans and Hyaluronan in Culprit Lesions Insights Into Plaque Erosion", ARTERIOSCLER THROMB VASE BIOL., vol. 22, no. 10, 31 October 2002 (2002-10-31), pages 1642 - 8, XP055613537
MULLER: "Circadian Variation and Triggers of Onset of Acute Cardiovascular Disease", CIRCULATION, vol. 79, no. 4, 1989, pages 733 - 43
NAGHAVI: "New Developments in the Detection of Vulnerable plaque", CURR ATHEROSCLER REP., vol. 3, no. 2, 2001, pages 125 - 35, XP008058664
NATURE PROTOCOLS,, vol. 1, no. 3, 2006, pages 1227 - 1234
J. AM, CHEM. SOC.,, vol. 124, 2002, pages 7892 - 7893
THIN SOLID FILMS, vol. 438-439, 2003, pages 20 - 26
MULLER: "Circadian Variation and Triggers of Onset of Acute Cardiovascular Disease", CIRCULATION, vol. 79, no. 4, 1989, pages 733 - 43
NAGHAVI: "New Developments in the Detection of Vulnerable plaque", CURR ATHEROSCLER REP., vol. 3, no. 2, 2001, pages 125 - 35, XP008058664
NATURE PROTOCOLS,, vol. 1, no. 3, 2006, pages 1227 - 1234
J. AM, CHEM. SOC.,, vol. 124, 2002, pages 7892 - 7893
THIN SOLID FILMS, vol. 438-439, 2003, pages 20 - 26
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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