Title:
CEREBRAL CIRCULATORY DISORDER DETECTION MARKER, CEREBRAL CIRCULATORY DISORDER DETECTION METHOD USING SAME, AND CEREBRAL CIRCULATORY DISORDER INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2015/125752
Kind Code:
A1
Abstract:
Provided are: a method for chemical detection of a cerebral circulatory disorder at an early stage in a subject; and furthermore, a simple inhibitor which is capable of taking effect early against cerebral circulatory disorders such as neonatal HIE and which does not require therapeutic hypothermia. Cerebral circulatory disorders are detected by using: gene products of genes comprising the base sequences shown in SEQ ID NO:1-12 or of mutant genes thereof; or cerebral circulatory disorder detection markers that comprise one portion thereof.
Inventors:
ITO MASAYUKI (JP)
AKAMATSU TOMOHISA (JP)
AKAMATSU TOMOHISA (JP)
Application Number:
PCT/JP2015/054199
Publication Date:
August 27, 2015
Filing Date:
February 17, 2015
Export Citation:
Assignee:
NAT CT NEUROLOGY & PSYCHIATRY (JP)
International Classes:
C12N15/09; A61K31/7088; A61K31/7105; A61K31/713; A61K39/395; A61K48/00; A61P9/10; A61P25/00; A61P43/00; C12Q1/68; G01N33/53
Other References:
J MOL NEUROSCI, vol. 49, no. 2, 2013, pages 320 - 327
NEUROSCI LETT, vol. 558, 13 January 2014 (2014-01-13), pages 143 - 148
REPRODUCTIVE SCI, vol. 20, no. 3 , Supp.1, 2013, pages 300A
DATABASE genbank [O] 21 May 2015 (2015-05-21), DEL PUERTO A ET AL: "Homo sapiens purinergic receptor P2Y, G-protein coupled, 13 (P2RY13), mRNA", XP055224186, retrieved from ncbi Database accession no. NM_176894
DEV NEUROSCI., vol. 36, no. 1, 11 February 2014 (2014-02-11), pages 64 - 72
DATABASE genbank [O] 16 October 2008 (2008-10-16), EBERT,L: "Homo sapiens full open reading frame cDNA clone RZPDo834B0914D for gene IL1A, interleukin 1, alpha; complete cds, incl. stopcodon", XP055223128, retrieved from ncbi Database accession no. CR457414
DATABASE genbank [O] 16 October 2008 (2008-10-16), HALLECK,A: "Homo sapiens full open reading frame cDNA clone RZPDo834D0323D for gene CCL4, chemokine (C-C motif) ligand 4; complete cds, incl. stopcodon", XP055223128, retrieved from ncbi Database accession no. CR542119
DATABASE genbank [O] 15 March 2015 (2015-03-15), retrieved from ncbi Database accession no. NM_ 003407
DATABASE genbank [O] 15 March 2015 (2015-03-15), FLOYEL T, ET AL: "Homo sapiens cathepsin H (CTSH), mRNA", XP055224306, retrieved from ncbi Database accession no. NM_004390
BIOCHIM BIOPHYS ACTA, vol. 1783, no. 5, 2008, pages 941 - 952
CYTOKINE, vol. 59, 2012, pages 433 - 441
EXP BIOL MED (MAYWOOD)., vol. 237, no. 9, 2012, pages 1093 - 1100
DATABASE genbank [O] 16 October 2008 (2008-10-16), XP055223128, retrieved from ncbi Database accession no. CR456704
DATABASE genbank [O] 15 March 2015 (2015-03-15), XP055223126, retrieved from ncbi Database accession no. NM_000019
BIOCHEM BIOPHYS RES COMMUN, vol. 438, 2013, pages 340 - 345
BIOCHEM BIOPHYS RES COMMUN, vol. 148, no. 3, 1987, pages 1412 - 1427
PHARMACOL REP, vol. 62, no. 2, 2010, pages 311 - 318
ENDOCRINOL, vol. 147, no. 8, 2006, pages 3851 - 3860
APOPTOSIS, vol. 17, 2012, pages 25 - 36
J CEREB BLOOD FLOW METAB., vol. 31, no. 3, 2011, pages 842 - 854
vol. 23, no. 8, 2007, pages 1464 - 1469
INFLAMM RES, vol. 62, 2013, pages 219 - 228
AM J PATHOL., vol. 4, no. 6, 18 June 2014 (2014-06-18), pages 1843 - 1852
NEUROSCI LETT, vol. 558, 13 January 2014 (2014-01-13), pages 143 - 148
REPRODUCTIVE SCI, vol. 20, no. 3 , Supp.1, 2013, pages 300A
DATABASE genbank [O] 21 May 2015 (2015-05-21), DEL PUERTO A ET AL: "Homo sapiens purinergic receptor P2Y, G-protein coupled, 13 (P2RY13), mRNA", XP055224186, retrieved from ncbi Database accession no. NM_176894
DEV NEUROSCI., vol. 36, no. 1, 11 February 2014 (2014-02-11), pages 64 - 72
DATABASE genbank [O] 16 October 2008 (2008-10-16), EBERT,L: "Homo sapiens full open reading frame cDNA clone RZPDo834B0914D for gene IL1A, interleukin 1, alpha; complete cds, incl. stopcodon", XP055223128, retrieved from ncbi Database accession no. CR457414
DATABASE genbank [O] 16 October 2008 (2008-10-16), HALLECK,A: "Homo sapiens full open reading frame cDNA clone RZPDo834D0323D for gene CCL4, chemokine (C-C motif) ligand 4; complete cds, incl. stopcodon", XP055223128, retrieved from ncbi Database accession no. CR542119
DATABASE genbank [O] 15 March 2015 (2015-03-15), retrieved from ncbi Database accession no. NM_ 003407
DATABASE genbank [O] 15 March 2015 (2015-03-15), FLOYEL T, ET AL: "Homo sapiens cathepsin H (CTSH), mRNA", XP055224306, retrieved from ncbi Database accession no. NM_004390
BIOCHIM BIOPHYS ACTA, vol. 1783, no. 5, 2008, pages 941 - 952
CYTOKINE, vol. 59, 2012, pages 433 - 441
EXP BIOL MED (MAYWOOD)., vol. 237, no. 9, 2012, pages 1093 - 1100
DATABASE genbank [O] 16 October 2008 (2008-10-16), XP055223128, retrieved from ncbi Database accession no. CR456704
DATABASE genbank [O] 15 March 2015 (2015-03-15), XP055223126, retrieved from ncbi Database accession no. NM_000019
BIOCHEM BIOPHYS RES COMMUN, vol. 438, 2013, pages 340 - 345
BIOCHEM BIOPHYS RES COMMUN, vol. 148, no. 3, 1987, pages 1412 - 1427
PHARMACOL REP, vol. 62, no. 2, 2010, pages 311 - 318
ENDOCRINOL, vol. 147, no. 8, 2006, pages 3851 - 3860
APOPTOSIS, vol. 17, 2012, pages 25 - 36
J CEREB BLOOD FLOW METAB., vol. 31, no. 3, 2011, pages 842 - 854
vol. 23, no. 8, 2007, pages 1464 - 1469
INFLAMM RES, vol. 62, 2013, pages 219 - 228
AM J PATHOL., vol. 4, no. 6, 18 June 2014 (2014-06-18), pages 1843 - 1852
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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