Title:
CEREBROVASCULAR REGENERATION/RECONSTRUCTION PROMOTERS AND NERVE TISSUE SECONDARY DEGENERATION INHIBITORS COMPRISING GINSENOSIDE RB¿1?
Document Type and Number:
WIPO Patent Application WO/2000/048608
Kind Code:
A1
Abstract:
Efficacious preparations for intravenous administration containing ginsenoside Rb¿1? or its salt which are useful as vascular regeneration/reconstruction promoters and nerve tissue secondary degeneration inhibitors. These preparations are useful particularly in regenerating and reconstructing the cerebrovascular network after cerebral stroke and inhibiting nerve tissue secondary degeneration.
Inventors:
SAKANAKA MASAHIRO (JP)
TANAKA JUNYA (JP)
SATO KOHJI (JP)
TANAKA JUNYA (JP)
SATO KOHJI (JP)
Application Number:
PCT/JP1999/006804
Publication Date:
August 24, 2000
Filing Date:
December 03, 1999
Export Citation:
Assignee:
JAPAN SCIENCE & TECH CORP (JP)
SAKANAKA MASAHIRO (JP)
TANAKA JUNYA (JP)
SATO KOHJI (JP)
SAKANAKA MASAHIRO (JP)
TANAKA JUNYA (JP)
SATO KOHJI (JP)
International Classes:
A61K9/08; A61K31/00; A61K31/704; A61P9/00; A61P25/00; A61P43/00; C07J9/00; C07J17/00; (IPC1-7): A61K31/704; A61K45/00; A61P25/00; A61P43/00; G01N33/15; G01N33/50
Domestic Patent References:
| WO1990008315A1 | 1990-07-26 |
Foreign References:
| JPH1036387A | 1998-02-10 |
Other References:
J.H. LIM ET AL.: "Protection of ischemic hippocampal neurons by ginsenoside Rb1, a main ingredient of ginseng root", NEUROSCIENCE RESEARCH,, vol. 28, 1997, pages 191 - 200, XP002926088
M. LIU ET AL.: "Protective effects of ginsenoside Rb1 and Rg1 on cultured hippocampal neurons", ACTA PHARMACEUTICA SINICA,, vol. 30, no. 9, 1995, pages 674 - 678, XP002926089
ZHANG YING-GE ET AL.: "Influences of ginsenosides Rb1 and Rg1 on reversible focal brain ischemia in rats", ACTA PHARMACOLOGICA SINICA,, vol. 17, no. 1, 1996, pages 44 - 48, XP002926090
XIU CHEN.: "Cardiovascular protection by ginsenosides and their nitric oxide reseasing action", CLINICAL AND PHARMACOLOGY AND PHYSIOLOGY,, vol. 23, 1996, pages 728 - 732, XP002926091
See also references of EP 1170012A4
M. LIU ET AL.: "Protective effects of ginsenoside Rb1 and Rg1 on cultured hippocampal neurons", ACTA PHARMACEUTICA SINICA,, vol. 30, no. 9, 1995, pages 674 - 678, XP002926089
ZHANG YING-GE ET AL.: "Influences of ginsenosides Rb1 and Rg1 on reversible focal brain ischemia in rats", ACTA PHARMACOLOGICA SINICA,, vol. 17, no. 1, 1996, pages 44 - 48, XP002926090
XIU CHEN.: "Cardiovascular protection by ginsenosides and their nitric oxide reseasing action", CLINICAL AND PHARMACOLOGY AND PHYSIOLOGY,, vol. 23, 1996, pages 728 - 732, XP002926091
See also references of EP 1170012A4
Attorney, Agent or Firm:
Saeki, Norio (Nihonbashi 3-chome Chuo-ku Tokyo, JP)
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