Title:
CERTAIN AMINOALKYL GLUCOSAMINIDE PHOSPHATE COMPOUNDS AND THEIR USE
Document Type and Number:
WIPO Patent Application WO2006016997
Kind Code:
A3
Abstract:
Compounds that are adjuvants and immunoeffectors are described and claimed. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Compositions and methods for using the compounds as adjuvants and immunoeffectors are also disclosed.
Inventors:
JOHNSON DAVID A (US)
PERSING DAVID H (US)
PERSING DAVID H (US)
Application Number:
PCT/US2005/022522
Publication Date:
December 07, 2006
Filing Date:
June 24, 2005
Export Citation:
Assignee:
CORIXA CORP (US)
JOHNSON DAVID A (US)
PERSING DAVID H (US)
JOHNSON DAVID A (US)
PERSING DAVID H (US)
International Classes:
C07H15/04; C07H5/02; C07H11/04; C07H13/04
Domestic Patent References:
| WO2001034617A2 | 2001-05-17 | |||
| WO2004062599A2 | 2004-07-29 | |||
| WO2004005308A2 | 2004-01-15 |
Other References:
PERSING, DAVID H. ET AL: "Taking toll: lipid A mimetics as adjuvants and immunomodulators", TRENDS IN MICROBIOLOGY , 10(10, SUPPL.), S32-S37 CODEN: TRMIEA; ISSN: 0966-842X, 2002, XP009067296
STOEVER, AXEL G. ET AL: "Structure-Activity Relationship of Synthetic Toll-like Receptor 4 Agonists", JOURNAL OF BIOLOGICAL CHEMISTRY , 279(6), 4440-4449 CODEN: JBCHA3; ISSN: 0021-9258, 2004, XP002396045
STOEVER, AXEL G. ET AL: "Structure-Activity Relationship of Synthetic Toll-like Receptor 4 Agonists", JOURNAL OF BIOLOGICAL CHEMISTRY , 279(6), 4440-4449 CODEN: JBCHA3; ISSN: 0021-9258, 2004, XP002396045
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