Title:
CHALCONE DERIVATIVE COMPOUND, OPTICAL ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING DISEASE CAUSED BY REDUCTION IN MITOCHONDRIAL OXYGEN CONSUMPTION RATE
Document Type and Number:
WIPO Patent Application WO/2018/062837
Kind Code:
A1
Abstract:
The present invention relates to a chalcone derivative compound, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an effective ingredient for preventing or treating diseases caused by reduction in a mitochondrial oxygen consumption rate. A pharmaceutical composition, when comprising the chalcone derivative compound, exerts excellent activity of increasing a mitochondrial oxygen consumption rate and can be usefully used for preventing or treating diseases caused by a reduction in the oxygen consumption rate of mitochondria, such as neurodegenerative diseases, attention deficit/hyperactivity disorder, schizophrenia, drug addiction, chronic renal failure, hepatic encephalopathy, and chronic liver disease.
Inventors:
HEO JUN YOUNG (KR)
KIM SOO JEONG (KR)
LEE MIN JOUNG (KR)
KWEON GI RYANG (KR)
KIM SOO JEONG (KR)
LEE MIN JOUNG (KR)
KWEON GI RYANG (KR)
Application Number:
PCT/KR2017/010701
Publication Date:
April 05, 2018
Filing Date:
September 27, 2017
Export Citation:
Assignee:
IAC IN NAT UNIV CHUNGNAM (KR)
International Classes:
A61K31/12; C07C49/235; C07C49/248
Foreign References:
| US20080009528A1 | 2008-01-10 | |||
| KR101149529B1 | 2012-05-25 |
Other References:
MATHEW, B. ET AL.: "Potent and Selective Monoamine Oxidase‐B Inhibitory Activity: Fluoro‐ vs. Trifluoromethyl‐4‐hydroxylated Chalcone Derivatives", CHERN. BIODIVERSITY, vol. 13, no. 8, 4 August 2016 (2016-08-04), pages 1046 - 1052, XP055499912
DATABASE REGISTRY [O] 2 July 2007 (2007-07-02), retrieved from STN Database accession no. RN 940845-38-5
DATABASE REGISTRY [O] 5 August 2003 (2003-08-05), retrieved from STN Database accession no. RN 561049-32-9
DATABASE REGISTRY [O] 2 July 2007 (2007-07-02), retrieved from STN Database accession no. RN 940845-38-5
DATABASE REGISTRY [O] 5 August 2003 (2003-08-05), retrieved from STN Database accession no. RN 561049-32-9
Attorney, Agent or Firm:
GHONG-GAN INTERNATIONAL PATENT LAW FIRM (KR)
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