Title:
CHARACTERISTIC ANALYSIS METHOD AND CLASSIFICATION OF PHARMACEUTICAL COMPONENTS BY USING TRANSCRIPTOMES
Document Type and Number:
WIPO Patent Application WO/2018/124293
Kind Code:
A1
Abstract:
The present invention provides a novel method for the classification of adjuvants. In one embodiment, the present invention provides a method for generating organ transcriptome profiles for adjuvants, said method comprising: (A) a step for obtaining expression data by performing transcriptome analysis for at least one organ of a target organism by using at least two adjuvants; (B) a step for clustering the adjuvants with respect to the expression data; and (C) a step for generating the organ transcriptome profile for the adjuvants on the basis of the clustering.
Inventors:
ISHII KEN (JP)
Application Number:
PCT/JP2017/047319
Publication Date:
July 05, 2018
Filing Date:
December 28, 2017
Export Citation:
Assignee:
NAT INST BIOMEDICAL INNOVATION HEALTH & NUTRITION (JP)
International Classes:
G01N33/50; C12M1/00; C12Q1/68; G01N33/49; G01N33/68
Domestic Patent References:
| WO2016079899A1 | 2016-05-26 | |||
| WO1987002679A1 | 1987-05-07 | |||
| WO2006024100A1 | 2006-03-09 | |||
| WO1990001949A1 | 1990-03-08 |
Foreign References:
| JP2012515533A | 2012-07-12 | |||
| JP2013523154A | 2013-06-17 | |||
| JP2002372532A | 2002-12-26 | |||
| JP2016506408A | 2016-03-03 | |||
| JP2006174827A | 2006-07-06 | |||
| JP2016515383A | 2016-05-30 | |||
| US20150051086A1 | 2015-02-19 | |||
| US20120178646A1 | 2012-07-12 | |||
| JP2016256270A | 2016-12-28 | |||
| JP2016256278A | 2016-12-28 |
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DESMET, C.J.ISHII, K.J.: "Nature reviews", IMMUNOLOGY, vol. 12, 2012, pages 479 - 491
JANEWAY, C.A., JR., COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, vol. 54, 1989, pages 1 - 13
MATZINGER, P., ANNU REV IMMUNOL, vol. 12, 1994, pages 991 - 1045
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TSANG, J.S. ET AL., CELL, vol. 157, 2014, pages 499 - 513
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SOBOLEV, O. ET AL., NATURE IMMUNOLOGY, vol. 17, 2016, pages 204 - 213
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AKAZAWA T. ET AL., CANCERSCI, vol. 101, 2010, pages 1596 - 1603
HEMMI, H. ET AL., NATURE, vol. 408, 2000, pages 740 - 745
KRIEG, A.M.: "Nature reviews", DRUG DISCOVERY, vol. 5, 2006, pages 471 - 484
BRAZOLOT MILLAN, C.L.WEERATNA, R.KRIEG, A.M.SIEGRIST, C.A.DAVIS, H.L., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 95, 1998, pages 15553 - 15558
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KLINMAN, D.M.: "Nature reviews", IMMUNOLOGY, vol. 4, 2004, pages 249 - 258
ADVANCED DRUG DELIVERY REVIEWS, vol. 61, 2009, pages 195 - 204
HARTMANN, G. ET AL., EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 33, 2003, pages 1633 - 1641
MARSHALL, J.D. ET AL., JOURNAL OF LEUKOCYTE BIOLOGY, vol. 73, 2003, pages 781 - 792
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PHELPS, CF: "The physical properties of inulin solutions", BIOCHEM J, vol. 95, 1965, pages 41 - 47, XP055405018, doi:10.1042/bj0950041
IGARASHI, Y. ET AL.: "Open TG-GATEs: a large-scale toxicogenomics database", NUCLEIC ACIDS RESEARCH, vol. 43, 2015, pages 921 - 927
CHEN, Y.A.TRIPATHI, L.P.MIZUGUCHI, K., PLOS ONE, vol. 6, 2011, pages el7844
HENG, T.S. ET AL., NATURE IMMUNOLOGY, vol. 9, 2008, pages 1091 - 1094
LEEK, J.T. ET AL., NAT REV GENET, vol. 11, 2010, pages 733 - 739
MARICHAL, T. ET AL., NAT MED, vol. 17, 2011, pages 996 - 1002
ONISHI, M. ET AL., JOURNAL OF IMMUNOLOGY, vol. 194, 2015, pages 2673 - 2682
VONO, M. ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110, 2013, pages 21095 - 21100
FALKEBORN, T. ET AL., PLOS ONE, vol. 8, 2013, pages e60038
MALTAIS, A.K. ET AL., VACCINE, vol. 32, 2014, pages 3307 - 3315
SAADE, F. ET AL., VACCINE, vol. 31, 2013, pages 1999 - 2007
GAO, P. ET AL., CELL, vol. 154, 2013, pages 748 - 762
STEINHAGEN, F. ET AL., JOURNAL OF LEUKOCYTE BIOLOGY, vol. 92, 2012, pages 775 - 785
MADHUN, A.S. ET AL., VACCINE, vol. 29, 2011, pages 4973 - 4982
WOODWARD, J.J. ET AL., SCIENCE, vol. 328, 2010, pages 1703 - 1705
TANAKA, M. ET AL., BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 57, 1993, pages 1602 - 1603
MIZUKAMI, T. ET AL., VACCINE, vol. 26, 2008, pages 2270 - 2283
MIZUKAMI, T. ET AL., PLOS ONE, vol. 9, 2014, pages el01835
DIDIERLAURENT, A.M. ET AL., JOURNAL OF IMMUNOLOGY, vol. 183, 2009, pages 6186 - 6197
KNUDSEN, N.P. ET AL., SCIENTIFIC REPORTS, vol. 6, 2016, pages 19570
IGARASHI, Y. ET AL., NUCLEIC ACIDS RESEARCH, vol. 43, 2015, pages 921 - 927
HARA ET AL., NATURE IMMUNOLOGY, vol. 8, 2007, pages 619 - 629
ARASE ET AL., J EXP MED, vol. 186, 1997, pages 1957 - 1963
TAKAI ET AL., CELL, vol. 76, 1994, pages 519 - 529
MARICHAL ET AL., NATURE MEDICINE, vol. 17, 2011, pages 996 - 1002
KOBIYAMA ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 111, 2014, pages 3086
KISTNER ET AL., PLOS ONE, vol. 5, 2010, pages e9349
NORDVALL, ALLERGY, vol. 37, 1982, pages 259 - 264
SUZUKI ET AL., J EXP MED, vol. 206, 2009, pages 1485 - 1493
AOSHI ET AL., EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 39, 2009, pages 417 - 425
AOSHI ET AL., IMMUNITY, vol. 29, 2008, pages 476 - 486
EISENBARTH ET AL., NATURE, vol. 453, 2008, pages 1122 - 1126
KURODA ET AL., INT REV IMMUNOL, vol. 32, 2013, pages 209 - 220
UEHARA, T. ET AL., TOXICOL APPL PHARMACOL, vol. 255, no. 3, 15 September 2011 (2011-09-15), pages 297 - 306
REED, S.G.ORR, M.T.FOX, C.B., NAT MED, vol. 19, 2013, pages 1597 - 1608
DESMET, C.J.ISHII, K.J.: "Nature reviews", IMMUNOLOGY, vol. 12, 2012, pages 479 - 491
JANEWAY, C.A., JR., COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, vol. 54, 1989, pages 1 - 13
MATZINGER, P., ANNU REV IMMUNOL, vol. 12, 1994, pages 991 - 1045
KAWAI, T.AKIRA, S., NATURE IMMUNOLOGY, vol. 11, 2010, pages 427 - 434
MATZINGER, P., ANNU REVIMMUNOL, vol. 12, 1994, pages 991 - 1045
SHOENFELD, Y.AGMON-LEVIN, N., JOURNAL OF AUTOIMMUNITY, vol. 36, 2011, pages 4 - 8
BATISTA-DUHARTE, A.LINDBLAD, E.B.OVIEDO-ORTA, E., TOXICOLOGY LETTERS, vol. 203, 2011, pages 97 - 105
HONDA-OKUBO, Y. ET AL., VACCINE, vol. 30, 2012, pages 5373 - 5381
STASSIJNS, J.BOLLAERTS, K.BAAY, M.VERSTRAETEN, T., VACCINE, vol. 34, 2016, pages 714 - 722
SUN, Y.GRUBER, M.MATSUMOTO, M., JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, vol. 65, 2012, pages 49 - 57
MASTELIC, B. ET AL., BIOLOGICALS, vol. 41, 2013, pages 115 - 124
PULENDRAN, B., PROC NATL ACAD SCI U S A, vol. 111, 2014, pages 12300 - 12306
RAVINDRAN, R. ET AL., SCIENCE, vol. 343, 2014, pages 313 - 317
TSANG, J.S. ET AL., CELL, vol. 157, 2014, pages 499 - 513
NAKAYA, H.I. ET AL., IMMUNITY, vol. 43, 2015, pages 1186 - 1198
SOBOLEV, O. ET AL., NATURE IMMUNOLOGY, vol. 17, 2016, pages 204 - 213
OLAFSDOTTIR, T.LINDQVIST, M.HARANDI, A.M., VACCINE, vol. 33, 2015, pages 5302 - 5307
HAYASHI, M. ET AL., SCIENTIFIC REPORTS, vol. 6, 2016
G.N.LANCEW.T.WILLIAMS, THE COMPUTER JOURNAL, vol. 9, 1967, pages 373 - 380
F.MURTAGH, THE COMPUTER JOURNAL, vol. 26, 1983, pages 354 - 359
C.F.OLSON, PARALLEL COMPUTING, vol. 21, 1995, pages 1313 - 1325
"DNA Maikuroarei to Saishin PCR ho'' [Cellular engineering, Extra issue, ''DNA Microarrays and Latest PCR Methods", article "DNA array, protein array). DNA arrays are outlined extensively"
NAT GENET., vol. 32, December 2002 (2002-12-01), pages 526 - 32
"Genomu Kaiseki Jikkenho Nakamura Yusuke Labo Manyuaru [Genome analysis experimental method Yusuke Nakamura Lab Manual", 2002, YODOSHA
J ANTIBIOT (TOKYO, vol. 36, no. 8, August 1983 (1983-08-01), pages 1045 - 50
AKAZAWA T. ET AL., CANCERSCI, vol. 101, 2010, pages 1596 - 1603
HEMMI, H. ET AL., NATURE, vol. 408, 2000, pages 740 - 745
KRIEG, A.M.: "Nature reviews", DRUG DISCOVERY, vol. 5, 2006, pages 471 - 484
BRAZOLOT MILLAN, C.L.WEERATNA, R.KRIEG, A.M.SIEGRIST, C.A.DAVIS, H.L., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 95, 1998, pages 15553 - 15558
CHU, R.S.TARGONI, O.S.KRIEG, A.M.LEHMANN, P.V.HARDING, C.V., THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 186, 1997, pages 1623 - 1631
KLINMAN, D.M.: "Nature reviews", IMMUNOLOGY, vol. 4, 2004, pages 249 - 258
ADVANCED DRUG DELIVERY REVIEWS, vol. 61, 2009, pages 195 - 204
HARTMANN, G. ET AL., EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 33, 2003, pages 1633 - 1641
MARSHALL, J.D. ET AL., JOURNAL OF LEUKOCYTE BIOLOGY, vol. 73, 2003, pages 781 - 792
SAMULOWITZ, U. ET AL., OLIGONUCLEOTIDES, vol. 20, 2010, pages 93 - 101
OLIVE, EXPERT REVIEW OF VACCINES, vol. 11, 2012, pages 237 - 256
KOYAMA, S.AOSHI, T.TANIMOTO, T.KUMAGAI, Y.KOBIYAMA, K.TOUGAN, T.SAKURAI, K.COBAN, C.HORII, T.AKIRA, S. ET AL., SCIENCE TRANSLATIONAL MEDICINE, vol. 2, 2010, pages 25ra24
PHELPS, CF: "The physical properties of inulin solutions", BIOCHEM J, vol. 95, 1965, pages 41 - 47, XP055405018, doi:10.1042/bj0950041
IGARASHI, Y. ET AL.: "Open TG-GATEs: a large-scale toxicogenomics database", NUCLEIC ACIDS RESEARCH, vol. 43, 2015, pages 921 - 927
CHEN, Y.A.TRIPATHI, L.P.MIZUGUCHI, K., PLOS ONE, vol. 6, 2011, pages el7844
HENG, T.S. ET AL., NATURE IMMUNOLOGY, vol. 9, 2008, pages 1091 - 1094
LEEK, J.T. ET AL., NAT REV GENET, vol. 11, 2010, pages 733 - 739
MARICHAL, T. ET AL., NAT MED, vol. 17, 2011, pages 996 - 1002
ONISHI, M. ET AL., JOURNAL OF IMMUNOLOGY, vol. 194, 2015, pages 2673 - 2682
VONO, M. ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110, 2013, pages 21095 - 21100
FALKEBORN, T. ET AL., PLOS ONE, vol. 8, 2013, pages e60038
MALTAIS, A.K. ET AL., VACCINE, vol. 32, 2014, pages 3307 - 3315
SAADE, F. ET AL., VACCINE, vol. 31, 2013, pages 1999 - 2007
GAO, P. ET AL., CELL, vol. 154, 2013, pages 748 - 762
STEINHAGEN, F. ET AL., JOURNAL OF LEUKOCYTE BIOLOGY, vol. 92, 2012, pages 775 - 785
MADHUN, A.S. ET AL., VACCINE, vol. 29, 2011, pages 4973 - 4982
WOODWARD, J.J. ET AL., SCIENCE, vol. 328, 2010, pages 1703 - 1705
TANAKA, M. ET AL., BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 57, 1993, pages 1602 - 1603
MIZUKAMI, T. ET AL., VACCINE, vol. 26, 2008, pages 2270 - 2283
MIZUKAMI, T. ET AL., PLOS ONE, vol. 9, 2014, pages el01835
DIDIERLAURENT, A.M. ET AL., JOURNAL OF IMMUNOLOGY, vol. 183, 2009, pages 6186 - 6197
KNUDSEN, N.P. ET AL., SCIENTIFIC REPORTS, vol. 6, 2016, pages 19570
IGARASHI, Y. ET AL., NUCLEIC ACIDS RESEARCH, vol. 43, 2015, pages 921 - 927
HARA ET AL., NATURE IMMUNOLOGY, vol. 8, 2007, pages 619 - 629
ARASE ET AL., J EXP MED, vol. 186, 1997, pages 1957 - 1963
TAKAI ET AL., CELL, vol. 76, 1994, pages 519 - 529
MARICHAL ET AL., NATURE MEDICINE, vol. 17, 2011, pages 996 - 1002
KOBIYAMA ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 111, 2014, pages 3086
KISTNER ET AL., PLOS ONE, vol. 5, 2010, pages e9349
NORDVALL, ALLERGY, vol. 37, 1982, pages 259 - 264
SUZUKI ET AL., J EXP MED, vol. 206, 2009, pages 1485 - 1493
AOSHI ET AL., EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 39, 2009, pages 417 - 425
AOSHI ET AL., IMMUNITY, vol. 29, 2008, pages 476 - 486
EISENBARTH ET AL., NATURE, vol. 453, 2008, pages 1122 - 1126
KURODA ET AL., INT REV IMMUNOL, vol. 32, 2013, pages 209 - 220
UEHARA, T. ET AL., TOXICOL APPL PHARMACOL, vol. 255, no. 3, 15 September 2011 (2011-09-15), pages 297 - 306
Attorney, Agent or Firm:
YAMAMOTO Shusaku et al. (JP)
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