Title:
CHECKPOINT-ACTIVATING OLIGONUCLEOTIDES
Document Type and Number:
WIPO Patent Application WO2001083703
Kind Code:
A3
Abstract:
The present invention provides polypeptides (Cds1) that are involved in regulating the progression of the cell cycle. The polypeptides are activated by double-stranded DNA and phosphorylated in response to the presence of double-stranded DNA. Also provided are polynucleotides encoding Cds1 polypeptides and methods for modulating cell cycle progression in a cell.
Inventors:
DUNPHY WILLIAM G
GUO ZIJIAN
GUO ZIJIAN
Application Number:
PCT/US2001/014646
Publication Date:
March 21, 2002
Filing Date:
May 04, 2001
Export Citation:
Assignee:
CALIFORNIA INST OF TECHN (US)
International Classes:
C07K14/47; (IPC1-7): A01N37/18; A01K67/00; A01K67/027; A01K67/033; A01N63/00; A61K38/00; A61K39/395; A61K48/00; C07H21/02; C07H21/04; C07K1/00; C07K14/00; C12N15/00; C12N15/09; C12N15/63; C12N15/70; C12N15/74; C12P21/04; C12Q1/68; G01N33/48; G01N33/50; C01K17/00
Foreign References:
| US6048693A | 2000-04-11 |
Other References:
DATABASE GENBANK [online] June 1999 (1999-06-01), SUGANO ET AL.: "WashU zebrafish EST project", XP002949222, accession no. NCBI Database accession no. AI667584
DATABASE GENBANK [online] April 2000 (2000-04-01), BARGUES ET AL., XP002949223, accession no. NCBI Database accession no. AL133363
GUO ET AL.: "Response of xenopus Cds1 in cell-free extracts to DNA template with double-stranded ends", MOLECULAR BIOLOGY OF THE CELL, vol. 11, May 2000 (2000-05-01), pages 1535 - 1546, XP002949220
FURNARI ET AL.: "Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1", MOLECULAR BIOLOGY OF THE CELL, vol. 10, April 1999 (1999-04-01), pages 833 - 845, XP002949221
DATABASE GENBANK [online] April 2000 (2000-04-01), BARGUES ET AL., XP002949223, accession no. NCBI Database accession no. AL133363
GUO ET AL.: "Response of xenopus Cds1 in cell-free extracts to DNA template with double-stranded ends", MOLECULAR BIOLOGY OF THE CELL, vol. 11, May 2000 (2000-05-01), pages 1535 - 1546, XP002949220
FURNARI ET AL.: "Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1", MOLECULAR BIOLOGY OF THE CELL, vol. 10, April 1999 (1999-04-01), pages 833 - 845, XP002949221
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