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Title:
CHELATE COMPOUND AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2016/052488
Kind Code:
A1
Abstract:
[Problem] To provide a chelate compound that has a high safety and is applicable to various uses. [Solution] A chelate compound wherein a chelate-forming moiety is attached to a base compound having an amino group and at least a part of the amino group is in the form of a halide salt. A specific example of the halide salt is hydrochloride. As the base compound, a chitosan having a glucosamine skeleton is preferred. Also, chitosan beads are usable. The chelate compound is produced by reacting the base compound having an amino group with an aldehyde group of an aromatic cyclic compound, said aromatic cyclic compound having at least a functional group capable of forming a chelate and the aldehyde group, to thereby form a Schiff base, reducing the Schiff base with a reducing agent and then treating with a hydrohalogenic acid (hydrochloric acid).

Inventors:
NISHIDA Yuzo (5-35-8, Awagasaki-machi, Kanazawa-sh, Ishikawa 26, 〒9200226, JP)
Application Number:
JP2015/077468
Publication Date:
April 07, 2016
Filing Date:
September 29, 2015
Export Citation:
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Assignee:
DISEASE ADSORPTION SYSTEM TECHNOLOGIES CO., LTD. (5-35-8, Awagasaki-machi Kanazawa-sh, Ishikawa 26, 〒9200226, JP)
International Classes:
C07H15/18; C08B37/08
Domestic Patent References:
WO2012096183A12012-07-19
WO1999020316A11999-04-29
Foreign References:
US4424346A1984-01-03
CN101126156A2008-02-20
JP2003221397A2003-08-05
JP2008512360A2008-04-24
Other References:
WACKER, OSKAR ET AL.: "Synthesis of D- glucopyrano-(cis-2',1'-c)-1,2,3,4- tetrahydroisoquinolines", HELVETICA CHIMICA ACTA, vol. 50, no. 8, 1967, pages 2481 - 2490
HALL, LAURANCE D. ET AL.: "Enhancement of the metal-chelating properties of chitin and chitosan", vol. 83, no. 1, 1980, pages C5 - C7, XP055424097, Retrieved from the Internet
BAYLY, SIMON R. ET AL.: "Carbohydrate Conjugates for Molecular Imaging and Radiotherapy: 99mTc(I) and 186Re(I) Tricarbonyl Complexes of N-(2'-Hydroxybenzyl)-2-amino-2- deoxy-D-glucose", BIOCONJUGATE CHEMISTRY, vol. 15, no. 4, 2004, pages 923 - 926, XP002422367, doi:10.1021/bc0499681
NADEEM, QAISAR ET AL.: "Synthesis, characterization and bioevaluation of technetium-99m labeled N-(2-Hydroxybenzyl)-2- amino-2-deoxy-D-glucose as a tumor imaging agent", PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 26, no. 2, 2013, pages 353 - 357, XP055424103
See also references of EP 3202773A4
Attorney, Agent or Firm:
ASANO Noriko (6-27-7, Konandai Konan-ku, Yokohama-sh, Kanagawa 54, 〒2340054, JP)
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