Title:
CHELATES OF METALS WHICH CAN BE ACTIVATED BY NEUTRONS AND THEIR USE FOR THE MEASUREMENT OF LABELED SPECIMENS
Document Type and Number:
WIPO Patent Application WO2002062397
Kind Code:
A3
Abstract:
Stable isotope labeling and neutron activation to measure biological functions are provided, as are the use and method of adding a chemical monitor to correct for neutron flux to sample vials prior to the addition of sample is presented, and the use of stable isotopes as a chemical bar code for vials and other items. Methods are provided also for measuring glomerular filtration rate and glomerular sieving function in a subject, and for measuring other physiological functions.
Inventors:
GROMAN ERNEST V (US)
REINHARDT CHRISTOPHER P (US)
REINHARDT CHRISTOPHER P (US)
Application Number:
PCT/US2002/005004
Publication Date:
December 05, 2002
Filing Date:
January 31, 2002
Export Citation:
Assignee:
BIOPHYSICS ASSAY LAB INC (US)
GROMAN ERNEST V (US)
REINHARDT CHRISTOPHER P (US)
GROMAN ERNEST V (US)
REINHARDT CHRISTOPHER P (US)
International Classes:
A61K33/242; A61K33/244; A61K41/00; A61K47/48; A61K51/04; A61K51/06; A61K51/12; (IPC1-7): A61K33/24; A61K49/00; A61K51/00
Foreign References:
| US5362476A | 1994-11-08 | |||
| US4647447A | 1987-03-03 | |||
| US5834456A | 1998-11-10 | |||
| US5674467A | 1997-10-07 | |||
| US5275801A | 1994-01-04 | |||
| US5284647A | 1994-02-08 | |||
| US5676923A | 1997-10-14 | |||
| US5277895A | 1994-01-11 | |||
| US6083479A | 2000-07-04 |
Other References:
CHOYKE P L ET AL: "HYDRATED CLEARANCE OF GADOLINIUM-DTPA AS A MEASUREMENT OF GLOMERULAR FILTRATION RATE", KIDNEY INTERNATIONAL, NEW YORK, NY, US, vol. 41, no. 6, 1992, pages 1595 - 1598, XP000933584, ISSN: 0085-2538
JING-LUEN A SHIH ET AL: "GADOLINIUM AS A NEUTRON CAPTURE THERAPY AGENT", MEDICAL PHYSICS, AMERICAN INSTITUTE OF PHYSICS. NEW YORK, US, vol. 19, no. 3, 1 May 1992 (1992-05-01), pages 733 - 744, XP000307312, ISSN: 0094-2405
HEIENE R: "The use of iohexol to measure glomerular filtration rate in the dog.", VETERINARY QUARTERLY, (1995 APR) 17 SUPPL 1 S36., XP001088101
MOMBELLI L ET AL: "[ Glomerular filtration rate estimated by measurement of the clearance of radioactive methylglucamine iothalamate]. Il filtrato glomerulare stimato dalla misura della clearance dello iotalamato di metilglucamina radioattivo.", RADIOLOGIA MEDICA, (1969 MAR) 55 (3) 242-7., XP001084714
BOHLEN H ET AL: "Differentiation of cytotoxicity using target cells labelled with europium and samarium by electroporation.", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 173, no. 1, 1994, pages 55 - 62, XP001087566, ISSN: 0022-1759
MATSUMURA AKIRA ET AL: "Mn-metalloporphyrin conjugated with Gd-DTPA (Gd-ATN10): Tumor enhancement agent for magnetic resonance imaging.", NEUROLOGIA MEDICO-CHIRURGICA, vol. 37, no. 4, 1997, pages 327 - 331, XP001084819, ISSN: 0470-8105
AKINE YASUYUKI ET AL: "Suppression of rabbit VX-2 subcutaneous tumor growth by gadolinium neutron capture therapy.", JAPANESE JOURNAL OF CANCER RESEARCH, vol. 84, no. 8, 1993, pages 841 - 843, XP001087571, ISSN: 0910-5050
KALE B D ET AL: "STABILITY CONSTANTS OF MIXED LIGAND CHELATES OF LANTHANUM-III PRASEODYMIUM-III AND NEODYMIUM-III WITH NTA HEDTA CYDTA AND DTPA AS PRIMARY LIGANDS AND SOME POLYMETHYLENE DICARBOXYLIC ACIDS AS SECONDARY LIGANDS", JOURNAL OF THE INDIAN CHEMICAL SOCIETY, vol. 67, no. 11, 1990, pages 901 - 902, XP001087572, ISSN: 0019-4522
ELSTER A D ET AL: "EUROPIUM DTPA A GADOLINIUM ANALOGUE TRACEABLE BY FLUORESCENCE MICROSCOPY", AJNR (AMERICAN JOURNAL OF NEURORADIOLOGY), vol. 10, no. 6, 1989, pages 1137 - 1144, XP001088052, ISSN: 0195-6108
DEAN, J.A.: "Lange's Handbook of Chemistry. Section 3-Atomic and molecular structure", 1985, MCGRAW-HILL, INC, NEW YORK, XP002207025
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 1990, MILKO V I ET AL: "[Use of DTPA-Yb 169 preparation for determination of glomerular filtration rate ]. Primenenie DTPA-Yb 166 dlia opredeleniia klubochkovoi fil'tratsii.", XP002207026, Database accession no. 74024757
FUNCK-BRENTANO J L ET AL: "A NEW METHOD FOR MEASURING GLOMERULAR FILTRATION WITHOUT URINE SAMPLES USING THE CLEARANCE OF DTPA DI ETHYLENE TRIAMINE PENTA ACETIC-ACID LANTHANUM-140 MEASURED BY EXTERNAL RADIOACTIVITY COUNTING", REVUE FRANCAISE D'ETUDES CLINIQUES ET BIOLOGIQUES, vol. 12, no. 8, 1967, pages 790 - 798, XP000108011
BIANCHI C ET AL: "The reliability of 140La-DTPA for the determination of glomerular filtration rate in man.", JOURNAL OF NUCLEAR BIOLOGY AND MEDICINE, (1973 OCT-DEC) 17 (4) 158-61., XP001084891
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2000, VASIL'EVA E.V., ET AL.: "Two quanta .gamma.-decays after capture of thermal neutrons in 139La nuclei", XP002207027, Database accession no. 134:77301
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1964, KONKS,V.A., ET AL.: "Cross sections for radiative capture of neutrons with energies up to 50KeV by 139La, 141Pr, 181Ta and 197Au", XP002207028, Database accession no. 60:80327
IKEDA N ET AL: "ACTIVATION ANALYSIS FOR TECHNETIUM-99 BY THE USE OF A NEUTRON-EXCITATION REACTION", JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol. 131, no. 1, 1989, pages 65 - 72, XP001088911, ISSN: 0236-5731
MOE L ET AL: "Estimation of glomerular filtration rate in dogs with 99M-Tc-DTPA and iohexol.", RESEARCH IN VETERINARY SCIENCE, (1995 MAR) 58 (2) 138-43., XP001088917
FAWDRY R M ET AL: "Comparative assessment of techniques for estimation of glomerular filtration rate with 99mTc-DTPA.", EUROPEAN JOURNAL OF NUCLEAR MEDICINE. GERMANY, WEST 1985, vol. 11, no. 1, 1985, pages 7 - 12, XP001088152, ISSN: 0340-6997
AWANG M B ET AL: "Radiolabelling of pharmaceutical dosage forms by neutron activation of samarium-152.", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 33, no. 10, 1993, pages 941 - 948, XP001088863, ISSN: 0362-4803
AWANG M B ET AL: "Evaluation of 153Sm-diethylenetriaminepentaacetic acid for radiolabelling of pharmaceutical dosage forms by neutron activation.", NUCLEAR MEDICINE AND BIOLOGY. ENGLAND OCT 1994, vol. 21, no. 7, October 1994 (1994-10-01), pages 905 - 909, XP001088906, ISSN: 0969-8051
JING-LUEN A SHIH ET AL: "GADOLINIUM AS A NEUTRON CAPTURE THERAPY AGENT", MEDICAL PHYSICS, AMERICAN INSTITUTE OF PHYSICS. NEW YORK, US, vol. 19, no. 3, 1 May 1992 (1992-05-01), pages 733 - 744, XP000307312, ISSN: 0094-2405
HEIENE R: "The use of iohexol to measure glomerular filtration rate in the dog.", VETERINARY QUARTERLY, (1995 APR) 17 SUPPL 1 S36., XP001088101
MOMBELLI L ET AL: "[ Glomerular filtration rate estimated by measurement of the clearance of radioactive methylglucamine iothalamate]. Il filtrato glomerulare stimato dalla misura della clearance dello iotalamato di metilglucamina radioattivo.", RADIOLOGIA MEDICA, (1969 MAR) 55 (3) 242-7., XP001084714
BOHLEN H ET AL: "Differentiation of cytotoxicity using target cells labelled with europium and samarium by electroporation.", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 173, no. 1, 1994, pages 55 - 62, XP001087566, ISSN: 0022-1759
MATSUMURA AKIRA ET AL: "Mn-metalloporphyrin conjugated with Gd-DTPA (Gd-ATN10): Tumor enhancement agent for magnetic resonance imaging.", NEUROLOGIA MEDICO-CHIRURGICA, vol. 37, no. 4, 1997, pages 327 - 331, XP001084819, ISSN: 0470-8105
AKINE YASUYUKI ET AL: "Suppression of rabbit VX-2 subcutaneous tumor growth by gadolinium neutron capture therapy.", JAPANESE JOURNAL OF CANCER RESEARCH, vol. 84, no. 8, 1993, pages 841 - 843, XP001087571, ISSN: 0910-5050
KALE B D ET AL: "STABILITY CONSTANTS OF MIXED LIGAND CHELATES OF LANTHANUM-III PRASEODYMIUM-III AND NEODYMIUM-III WITH NTA HEDTA CYDTA AND DTPA AS PRIMARY LIGANDS AND SOME POLYMETHYLENE DICARBOXYLIC ACIDS AS SECONDARY LIGANDS", JOURNAL OF THE INDIAN CHEMICAL SOCIETY, vol. 67, no. 11, 1990, pages 901 - 902, XP001087572, ISSN: 0019-4522
ELSTER A D ET AL: "EUROPIUM DTPA A GADOLINIUM ANALOGUE TRACEABLE BY FLUORESCENCE MICROSCOPY", AJNR (AMERICAN JOURNAL OF NEURORADIOLOGY), vol. 10, no. 6, 1989, pages 1137 - 1144, XP001088052, ISSN: 0195-6108
DEAN, J.A.: "Lange's Handbook of Chemistry. Section 3-Atomic and molecular structure", 1985, MCGRAW-HILL, INC, NEW YORK, XP002207025
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 1990, MILKO V I ET AL: "[Use of DTPA-Yb 169 preparation for determination of glomerular filtration rate ]. Primenenie DTPA-Yb 166 dlia opredeleniia klubochkovoi fil'tratsii.", XP002207026, Database accession no. 74024757
FUNCK-BRENTANO J L ET AL: "A NEW METHOD FOR MEASURING GLOMERULAR FILTRATION WITHOUT URINE SAMPLES USING THE CLEARANCE OF DTPA DI ETHYLENE TRIAMINE PENTA ACETIC-ACID LANTHANUM-140 MEASURED BY EXTERNAL RADIOACTIVITY COUNTING", REVUE FRANCAISE D'ETUDES CLINIQUES ET BIOLOGIQUES, vol. 12, no. 8, 1967, pages 790 - 798, XP000108011
BIANCHI C ET AL: "The reliability of 140La-DTPA for the determination of glomerular filtration rate in man.", JOURNAL OF NUCLEAR BIOLOGY AND MEDICINE, (1973 OCT-DEC) 17 (4) 158-61., XP001084891
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2000, VASIL'EVA E.V., ET AL.: "Two quanta .gamma.-decays after capture of thermal neutrons in 139La nuclei", XP002207027, Database accession no. 134:77301
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1964, KONKS,V.A., ET AL.: "Cross sections for radiative capture of neutrons with energies up to 50KeV by 139La, 141Pr, 181Ta and 197Au", XP002207028, Database accession no. 60:80327
IKEDA N ET AL: "ACTIVATION ANALYSIS FOR TECHNETIUM-99 BY THE USE OF A NEUTRON-EXCITATION REACTION", JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol. 131, no. 1, 1989, pages 65 - 72, XP001088911, ISSN: 0236-5731
MOE L ET AL: "Estimation of glomerular filtration rate in dogs with 99M-Tc-DTPA and iohexol.", RESEARCH IN VETERINARY SCIENCE, (1995 MAR) 58 (2) 138-43., XP001088917
FAWDRY R M ET AL: "Comparative assessment of techniques for estimation of glomerular filtration rate with 99mTc-DTPA.", EUROPEAN JOURNAL OF NUCLEAR MEDICINE. GERMANY, WEST 1985, vol. 11, no. 1, 1985, pages 7 - 12, XP001088152, ISSN: 0340-6997
AWANG M B ET AL: "Radiolabelling of pharmaceutical dosage forms by neutron activation of samarium-152.", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 33, no. 10, 1993, pages 941 - 948, XP001088863, ISSN: 0362-4803
AWANG M B ET AL: "Evaluation of 153Sm-diethylenetriaminepentaacetic acid for radiolabelling of pharmaceutical dosage forms by neutron activation.", NUCLEAR MEDICINE AND BIOLOGY. ENGLAND OCT 1994, vol. 21, no. 7, October 1994 (1994-10-01), pages 905 - 909, XP001088906, ISSN: 0969-8051
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