Title:
CHEMICAL COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/034153
Kind Code:
A1
Abstract:
Provided are a pyrimidinyl amino compound having protein kinase inhibitor activity, and a pharmaceutical composition containing said compound; also provided are a use and application of said compound. What is provided is selected from a group consisting of the compound represented by formula (I), a stereoisomer thereof, a tautomer thereof, a pharmacologically acceptable salt thereof, a solvate thereof, and a prodrug thereof. The described compound has good inhibitory activity against the JAK family of kinases and the SYK family of kinases, and therefore may serve as a JAK inhibitor and SYK inhibitor, and is effective in use for the prevention or treatment of diseases related to the JAK and SYK families of kinases.
Inventors:
ZHAO TAO (CN)
WEI DONG (CN)
LI MIN (CN)
KIM MAENG SUP (CN)
CHUL WOONG CHUNG (CN)
WEI DONG (CN)
LI MIN (CN)
KIM MAENG SUP (CN)
CHUL WOONG CHUNG (CN)
Application Number:
PCT/CN2018/101128
Publication Date:
February 21, 2019
Filing Date:
August 17, 2018
Export Citation:
Assignee:
BEIJING HANMI PHARM CO LTD (CN)
International Classes:
C07D239/48; A61K31/506; A61P29/00; A61P35/00; A61P37/00; C07D413/12; C07D413/14; C07D498/00
Domestic Patent References:
| WO2013169401A1 | 2013-11-14 |
Foreign References:
| CN102083800A | 2011-06-01 | |||
| CN104262328A | 2015-01-07 | |||
| CN101903357A | 2010-12-01 | |||
| CN102740847A | 2012-10-17 | |||
| CN201710713389A | 2017-08-18 |
Other References:
See also references of EP 3670500A4
Attorney, Agent or Firm:
UNI-INTEL PATENT AND TRADEMARK LAW FIRM (CN)
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