Title:
CHEMICAL INHIBITOR OF P53-SNAIL BINDING AND PHARMACEUTICAL COMPOSITION FOR TREATING CANCER DISEASE CONTAINING SAME AS ITS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2010/059004
Kind Code:
A2
Abstract:
The present invention relates to a chemical inhibitor of p53-Snail binding and to a pharmaceutical composition for treating cancer diseases containing the same as its active ingredient. The chemical inhibitor of p53-Snail binding induces expression of p-53 in K-Ras mutant cell lines, and thus can effectively treat or prevent K-Ras mutant cancer diseases that may not be easily diagnosed or treated, such as pancreatic cancer, lung cancer, cholangioma, and colon cancer.
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Inventors:
PARK BUM JOON (KR)
HA NAM CHUL (KR)
LEE SUN HYE (KR)
SONG GYU YONG (KR)
LEE JEE HYUN (KR)
HA NAM CHUL (KR)
LEE SUN HYE (KR)
SONG GYU YONG (KR)
LEE JEE HYUN (KR)
Application Number:
PCT/KR2009/006896
Publication Date:
May 27, 2010
Filing Date:
November 23, 2009
Export Citation:
Assignee:
PUSAN NAT UNIV IND COOP FOUND (KR)
IAC IN NAT UNIV CHUNGNAM (KR)
PARK BUM JOON (KR)
HA NAM CHUL (KR)
LEE SUN HYE (KR)
SONG GYU YONG (KR)
LEE JEE HYUN (KR)
IAC IN NAT UNIV CHUNGNAM (KR)
PARK BUM JOON (KR)
HA NAM CHUL (KR)
LEE SUN HYE (KR)
SONG GYU YONG (KR)
LEE JEE HYUN (KR)
International Classes:
C07C317/36; A61K31/10; A61K31/122; A61K48/00; A61P35/00; C12N15/09
Foreign References:
| CN1827578A | 2006-09-06 | |||
| JPS6133138A | 1986-02-17 | |||
| US5259849A | 1993-11-09 | |||
| US20050032794A1 | 2005-02-10 |
Other References:
NEOPLASIA, vol. 11, 2009, pages 1 - 10
See also references of EP 2377849A4
See also references of EP 2377849A4
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
특허법인태백 (KR)
특허법인태백 (KR)
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