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Title:
CHEMICAL INHIBITOR OF P53-SNAIL BINDING AND PHARMACEUTICAL COMPOSITION FOR TREATING CANCER DISEASE CONTAINING SAME AS ITS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2010/059004
Kind Code:
A3
Abstract:
The present invention relates to a chemical inhibitor of p53-Snail binding and to a pharmaceutical composition for treating cancer diseases containing the same as its active ingredient. The chemical inhibitor of p53-Snail binding induces expression of p-53 in K-Ras mutant cell lines, and thus can effectively treat or prevent K-Ras mutant cancer diseases that may not be easily diagnosed or treated, such as pancreatic cancer, lung cancer, cholangioma, and colon cancer.

Inventors:
PARK BUM JOON (KR)
HA NAM CHUL (KR)
LEE SUN HYE (KR)
SONG GYU YONG (KR)
LEE JEE HYUN (KR)
Application Number:
PCT/KR2009/006896
Publication Date:
September 10, 2010
Filing Date:
November 23, 2009
Export Citation:
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Assignee:
PUSAN NAT UNIV IND COOP FOUND (KR)
IAC IN NAT UNIV CHUNGNAM (KR)
PARK BUM JOON (KR)
HA NAM CHUL (KR)
LEE SUN HYE (KR)
SONG GYU YONG (KR)
LEE JEE HYUN (KR)
International Classes:
C07C317/36; A61K31/10; A61K31/122; A61K48/00; A61P35/00; C12N15/09
Foreign References:
CN1827578A2006-09-06
JPS6133138A1986-02-17
US5259849A1993-11-09
US20050032794A12005-02-10
Other References:
SHEN, GUI-NAN. ET AL.: "2-substituted thio- and amino-5, 8-dimethoxy-1, 4-naphthoquinones as a novel class of acyl-CoA: Cholesterol acyltransferase inhibitors", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 30, no. 6, June 2009 (2009-06-01), pages 1416
SHEN, GUI-NAN. ET AL.: "2-substituted thio- and amino-5, 8-dimethoxy-1, 4-naphthoquinones as a novel class of acyl-CoA: cholesterol acyltransferase inhibitors", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 30, no. 5, May 2009 (2009-05-01), pages 1088 - 1092
COULADOUROS, E. A. ET AL.: "Product class 3: naphtho-1, 4-quinones", SCIENCE OF SYNTHESIS, vol. 28, 2006, pages 217 - 322, XP009155284
VERMA, R. P. ET AL.: "Elucidation of structure-activity relationships for 2- or 6- substituted-5, 8-dimethoxy-1, 4-naphthoquinones", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, no. 22, 2004, pages 5997 - 6009, XP004604974, DOI: doi:10.1016/j.bmc.2004.08.017
TAPIA, R. A. ET AL.: "Synthesis of furanonaphthazarin derivatives", HETEROCYCLES, vol. 48, no. 7, 1998, pages 1365 - 1371
See also references of EP 2377849A4
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (60-4Gasan-dong, Geumcheon-gu, Seoul 153-770, KR)
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