Title:
CHEMICAL SYNTHESIS METHOD FOR O-ANTIGEN OLIGOSACCHARIDE OF PLESIOMONAS SHIGELLOIDES SEROTYPE O51
Document Type and Number:
WIPO Patent Application WO/2019/144508
Kind Code:
A1
Abstract:
Disclosed is a chemical synthesis method for an O-antigen oligosaccharide of Plesiomonas shigelloides serotype O51, which method belongs to the field of chemistry. In the present invention, source-rich D-glucose, L-fucose, D-glucosamine, etc., are used as raw materials to prepare three glycosylated building blocks, a synthetic route composed of 11 reaction modules is designed, and the preparation of the target oligosaccharide chain is successfully completed by the optimization of protecting groups and the optimization of the timing of introduction of modifying groups. The raw materials of the oligosaccharide chain prepared in the present invention are cheap and readily available, the preparation method therefor is simple and repeatable, and same has a good application prospect in the development of new drugs and vaccines for Plesimonas shigelloides, etc.
Inventors:
YIN JIAN (CN)
HU JING (CN)
PETER SEEBERGER (CN)
QIN CHUNJUN (CN)
HU JING (CN)
PETER SEEBERGER (CN)
QIN CHUNJUN (CN)
Application Number:
PCT/CN2018/082660
Publication Date:
August 01, 2019
Filing Date:
April 11, 2018
Export Citation:
Assignee:
UNIV JIANGNAN (CN)
International Classes:
A61K39/112; C08B37/00; A61P31/00
Other References:
QIN, CHUNJUN ET AL.: "Total Synthesis of a Densely Functionalized Plesiomonas Shigelloides Serotype 51 Aminoglycoside Trisaccharide Antigen", J. AM. CHEM. SOC., vol. 140, no. 8, 29 January 2018 (2018-01-29), pages 3120 - 3127, XP055627596
MACIEJEWSKA, A. ET AL.: "Structural Analysis of the O-Specific Polysaccharide Isolated from Plesiomonas Shigelloides 051 Lipopolysaccharide", CARBOHYDR. RES., vol. 344, no. 7, 12 May 2009 (2009-05-12), pages 894 - 900, XP026024007, doi:10.1016/j.carres.2009.02.020
MACIEJEWSKA, A. ET AL.: "Structural Analysis of the O-Specific Polysaccharide Isolated from Plesiomonas Shigelloides 051 Lipopolysaccharide", CARBOHYDR. RES., vol. 344, no. 7, 12 May 2009 (2009-05-12), pages 894 - 900, XP026024007, doi:10.1016/j.carres.2009.02.020
Attorney, Agent or Firm:
HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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