Title:
CHEMICAL SYNTHESIS OF NUCLEOSIDES ANALOGS AND THEIR INCORPORATION INTO POLYNUCLEOTIDES
Document Type and Number:
WIPO Patent Application WO1998028317
Kind Code:
A3
Abstract:
Novel nucleosides, process for chemical synthesis of nucleosides and incorporation of the nucleosides into polynucleotides are disclosed. Also described are polynucleotides, such as antisense, TFO and nucleic acid catalysts with one or more modifications, such as 2'-O-amino, L-nucleotides and the others.
Inventors:
KARPEISKY ALEXANDER
BEIGELMAN LEONID
MATULIC-ADAMIC JASENKA
BEIGELMAN LEONID
MATULIC-ADAMIC JASENKA
Application Number:
PCT/US1997/023936
Publication Date:
September 03, 1998
Filing Date:
December 19, 1997
Export Citation:
Assignee:
RIBOZYME PHARM INC (US)
International Classes:
A61K31/7056; A61K31/706; C12N9/22; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61K31/7115; A61P31/12; A61P35/00; C07H19/04; C07H19/048; C07H19/052; C07H19/06; C07H19/067; C07H19/10; C07H19/16; C07H19/167; C07H21/00; C07H21/02; C07K14/08; C12N5/10; C12N15/113; C12N15/85; C12N15/86; C12Q1/70; (IPC1-7): C07H19/00; C07H21/00
Domestic Patent References:
| WO1995011304A1 | 1995-04-27 | |||
| WO1995001363A1 | 1995-01-12 | |||
| WO1995011910A1 | 1995-05-04 | |||
| WO1996018736A2 | 1996-06-20 | |||
| WO1993012130A1 | 1993-06-24 |
Foreign References:
| EP0227844A1 | 1987-07-08 |
Other References:
M.PERBOST ET AL.: "Synthesis of 5'-O-Amino-2'-deoxypyrimidine and Purine Nucleosides : Building-Blocks for Antisense Oligonucleotides.", JOURNAL OF ORGANIC CHEMISTRY, vol. 60, no. 16, 11 August 1995 (1995-08-11), pages 5150 - 5156, XP002062165
K.BURGESS ET AL.: "Synthesis of an Oxyamide Linked Nucleotide Dimer and Incorporation into Antisense Oligonucleotide Sequences.", JOURNAL OF THE CHEMICAL SOCIETY CHEMICAL COMMUNICATIONS, 21 April 1994 (1994-04-21), pages 915 - 916, XP002062166
K.BURGESS ET AL.: "Synthesis of an Oxyamide Linked Nucleotide Dimer and Incorporation into Antisense Oligonucleotide Sequences.", JOURNAL OF THE CHEMICAL SOCIETY CHEMICAL COMMUNICATIONS, 21 April 1994 (1994-04-21), pages 915 - 916, XP002062166
Download PDF: