CHEMICALLY DERIVATIZED CD4 AND USES THEREOF

Title:

CHEMICALLY DERIVATIZED CD4 AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2007/075414

Kind Code:

A3

Abstract:

This invention provides two soluble polypeptides which comprise a portion of CD4 comprising all HIV gpl20-binding epitopes present on intact CD4, wherein the polypeptide has a cysteine substitution at a residue which, in intact CD4, interfaces with HIV gpl20. This invention provides also provides a method for making a derivatized soluble polypeptide and a method for obtaining a structural model useful in the design of an agent for inhibiting CD4 binding to HIV gpl20.

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Inventors:

HENDRICKSON WAYNE A (US)
XIE HUI (US)
SMITH AMOS B (US)
NG DANNY (US)

Application Number:

PCT/US2006/047907

Publication Date:

November 20, 2008

Filing Date:

December 14, 2006

Export Citation:

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Assignee:

UNIV COLUMBIA (US)
UNIV PENNSYLVANIA (US)
HENDRICKSON WAYNE A (US)
XIE HUI (US)
SMITH AMOS B (US)
NG DANNY (US)

International Classes:

C07K1/00; C07K14/00; C07K17/00; G01N31/00

Foreign References:

US20050176642A1	2005-08-11
US5632898A	1997-05-27

Other References:

WU H. ET AL.: "Kinetic and structural analysi of mutant CD4 receptors that are defective in HIV gp120 binding", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 93, no. 26, 24 December 1996 (1996-12-24), pages 15030 - 15035, XP002987138
BRODSKY M.H. ET AL.: "Analysis of the site in CD4 that binds to the HIV envelope glycoprotein", JOURNAL OF IMMUNOLOGY, vol. 144, no. 8, 15 April 1990 (1990-04-15), pages 3078 - 3086, XP000578392
KWONG ET AL.: "Oligomeric Modeling and electrostatic Analysis of the gp120 Envelope Glycoprotein of Human Immunodeficiency Virus", JOURNAL OF VIROLOGY, vol. 74, no. 4, February 2000 (2000-02-01), pages 1961 - 1972

Attorney, Agent or Firm:

WHITE, John, P. (1185 Avenue Of The AmericasNew York, NY, US)

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