Title:
CHEMICALLY MODIFIED HIV ENVELOPE GLYCOPROTEIN
Document Type and Number:
WIPO Patent Application WO2001049720
Kind Code:
A3
Abstract:
The invention relates to an HIV envelope glycoprotein in a purified form which can be obtained using a method comprising the following steps: (1) obtaining an envelope glycoprotein in a purified form; (2) reducing at least one disulphide bond of the protein from step (1); (3) alkylating at least two free sulfhydryl groups; (4) optionally, oxidizing the remaining sulfhydryl group; (5) denaturing and (6) renaturing. The invention also relates to the use of the inventive modified HIV envelope glycoprotein in a vaccine against HIV which can be used to induce HIV-neutralising antibodies in a human subject for therapeutic or prophylactic purposes.
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Inventors:
BOUDET FLORENCE (FR)
CHEVALIER MICHEL (FR)
DUBAYLE JEAN (FR)
EL HABIB RAPHAELLE (FR)
CHEVALIER MICHEL (FR)
DUBAYLE JEAN (FR)
EL HABIB RAPHAELLE (FR)
Application Number:
PCT/FR2000/003690
Publication Date:
May 23, 2002
Filing Date:
December 27, 2000
Export Citation:
Assignee:
AVENTIS PASTEUR (FR)
BOUDET FLORENCE (FR)
CHEVALIER MICHEL (FR)
DUBAYLE JEAN (FR)
EL HABIB RAPHAELLE (FR)
BOUDET FLORENCE (FR)
CHEVALIER MICHEL (FR)
DUBAYLE JEAN (FR)
EL HABIB RAPHAELLE (FR)
International Classes:
A61P31/18; C07K14/16; C07K16/10; A61K39/00; (IPC1-7): C07K14/16; C07K16/10; A61K38/16
Other References:
J S MCDOUGAL ET AL.: "Binding of the human retrovirus HTLV-III/LAV/ARV/HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody inhibition and potential for idiotypic mimicry", JOURNAL OF IMMUNOLOGY, vol. 137, no. 9, 1 November 1986 (1986-11-01), BALTIMORE US, pages 2937 - 2944, XP002150425
DATABASE CHEMABS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1997, B B JRAD & E BAHRAOUI: "Linear and yclic peptides mimicking the disulfide loops in HIV-2 envelope glycoprotein induced antibodies with different specificity", XP002150426
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KIENZLE, NORBERT ET AL: "Oligomerization of the Nef protein from human immunodeficiency virus (HIV) type 1", XP002173290, retrieved from STN Database accession no. 119:89376 CA
DATABASE CHEMABS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1997, B B JRAD & E BAHRAOUI: "Linear and yclic peptides mimicking the disulfide loops in HIV-2 envelope glycoprotein induced antibodies with different specificity", XP002150426
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KIENZLE, NORBERT ET AL: "Oligomerization of the Nef protein from human immunodeficiency virus (HIV) type 1", XP002173290, retrieved from STN Database accession no. 119:89376 CA
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