Title:
CHEMICALLY-MODIFIED HUMAN GROWTH HORMONE CONJUGATES
Document Type and Number:
WIPO Patent Application WO2005000359
Kind Code:
A3
Abstract:
The present invention provides a chemically modified human Growth Hormone (hGH) prepared by binding a water soluble polymer to the protein. The chemically-modified protein according to the present invention may have a much longer lasting hGH activity than that of the unmodified hGH, enabling reduced dose and scheduling opportunities.
More Like This:
| JP4334348 | Improved internal man-made device |
| JPS57182301 | COMPOSITE BODY OF SUGAR-CONTAINING COMPOUND AND CYCLOAMLOSE AND MANUFACTURE |
| WO/2002/083655 | PRODRUGS OF COX-2 INHIBITORS |
Inventors:
FINN RORY F (US)
SIEGEL NED R (US)
SIEGEL NED R (US)
Application Number:
PCT/US2003/015760
Publication Date:
June 16, 2005
Filing Date:
May 20, 2003
Export Citation:
Assignee:
PHARMACIA CORP (US)
FINN RORY F (US)
SIEGEL NED R (US)
FINN RORY F (US)
SIEGEL NED R (US)
International Classes:
A61K47/48; C07K14/61; (IPC1-7): A61K47/48
Domestic Patent References:
| WO2002009766A1 | 2002-02-07 | |||
| WO2002055532A2 | 2002-07-18 | |||
| WO2002098452A1 | 2002-12-12 | |||
| WO2003044056A2 | 2003-05-30 |
Other References:
CLARK R ET AL: "Long-acting growth hormones produced by conjugation with polyethylene glycol", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 36, 6 September 1996 (1996-09-06), pages 21969 - 21977, XP002216386, ISSN: 0021-9258
OLSON K. ET AL: "Preparation and characterization of PEGylated human growth hormone and human growth hormone mutants", JOURNAL, vol. -, 1997, pages 568 - 569, XP008040602
THORNER M O ET AL: "Growth hormone (GH) receptor blockade with a PEG-modified GH (B2036-PEG) lowers serum insulin-like growth factor-I but does not acutely stimulate serum GH", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, NEW YORK, NY, US, vol. 84, no. 6, June 1999 (1999-06-01), pages 2098 - 2103, XP002237939, ISSN: 0021-972X
PASUT G ET AL: "PROTEIN, PEPTIDE AND NON-PEPTIDE DRUG PEGYLATION FOR THERAPEUTIC APPLICATION", EXPERT OPINION ON THERAPEUTIC PATENTS, ASHLEY PUBLICATIONS, GB, vol. 14, no. 6, 2004, pages 859 - 894, XP001202106, ISSN: 1354-3776
OLSON K. ET AL: "Preparation and characterization of PEGylated human growth hormone and human growth hormone mutants", JOURNAL, vol. -, 1997, pages 568 - 569, XP008040602
THORNER M O ET AL: "Growth hormone (GH) receptor blockade with a PEG-modified GH (B2036-PEG) lowers serum insulin-like growth factor-I but does not acutely stimulate serum GH", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, NEW YORK, NY, US, vol. 84, no. 6, June 1999 (1999-06-01), pages 2098 - 2103, XP002237939, ISSN: 0021-972X
PASUT G ET AL: "PROTEIN, PEPTIDE AND NON-PEPTIDE DRUG PEGYLATION FOR THERAPEUTIC APPLICATION", EXPERT OPINION ON THERAPEUTIC PATENTS, ASHLEY PUBLICATIONS, GB, vol. 14, no. 6, 2004, pages 859 - 894, XP001202106, ISSN: 1354-3776
Download PDF:
Previous Patent: CHEMICAL COMBINATION AND METHOD FOR INCREASING DELIVERY OF COENZYME Q 10
Next Patent: PEG DERIVATIVES HAVING AN AMIDOCARBONATE LINKAGE
Next Patent: PEG DERIVATIVES HAVING AN AMIDOCARBONATE LINKAGE