Title:
CHEMICALLY MODIFIED SINGLE-STRANDED RNA-EDITING OLIGONUCLEOTIDES
Document Type and Number:
WIPO Patent Application WO/2018/041973
Kind Code:
A9
Abstract:
The invention relates to antisense oligonucleotides that are capable of bringing about specific editing of a target nucleotide (adenosine) in a target RNA sequence in a eukaryotic cell, wherein said oligonucleotide does not, in itself, form an intramolecular hairpin or stem-loop structure, and wherein said oligonucleotide comprises a non-complementary nucleotide in a position opposite to the nucleotide to be edited in the target RNA sequence.
Inventors:
TURUNEN JANNE JUHA (NL)
AALTO ANTTI (NL)
KLEIN BART (NL)
VAN SINT FIET LENKA (NL)
BOUDET JULIEN AUGUSTE GERMAIN (NL)
AALTO ANTTI (NL)
KLEIN BART (NL)
VAN SINT FIET LENKA (NL)
BOUDET JULIEN AUGUSTE GERMAIN (NL)
Application Number:
PCT/EP2017/071912
Publication Date:
May 09, 2019
Filing Date:
August 31, 2017
Export Citation:
Assignee:
PROQR THERAPEUTICS II BV (NL)
International Classes:
C12N15/113; A61K31/712; C12N15/10
Attorney, Agent or Firm:
SPINNER, David et al. (GB)
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