CHEMOENZYMATIC PROCESS FOR THE SYNTHESIS OF ESCITALOPRAM

Title:

CHEMOENZYMATIC PROCESS FOR THE SYNTHESIS OF ESCITALOPRAM

Document Type and Number:

WIPO Patent Application WO2006136521

Kind Code:

A8

Abstract:

A process is described for the preparation of escitalopram and the pharmaceutically acceptable salts thereof starting from 5-cyanophthalide by a process which provides an enantioselective enzymatic deacylation reaction of a complex of the formula (IV) where R represents a C₁-C₄ alkyl residue or an aryl residue under the action of an esterase from Aspergillus niger.

Inventors:

COTTICELLI GIOVANNI (IT)
SALVETTI RAUL (IT)
BERTONI CHIARA (IT)

Application Number:

PCT/EP2006/063193

Publication Date:

March 08, 2007

Filing Date:

June 14, 2006

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Assignee:

ADORKEM TECHNOLOGY SPA (IT)
COTTICELLI GIOVANNI (IT)
SALVETTI RAUL (IT)
BERTONI CHIARA (IT)

International Classes:

C12P13/02; C07C255/34; C07D307/87; C12P9/00; C12P17/04

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