Title:
CHEMOTHERAPY FOR CANCER USING AZABICYCLO COMPOUND
Document Type and Number:
WIPO Patent Application WO/2019/004417
Kind Code:
A1
Abstract:
Provided are a novel method for treating cancer, said method exhibiting a remarkably excellent antitumor effect with little side effect, and an immunostimulant. An antitumor agent and an immunostimulant, characterized by comprising an azabicyclo compound and an immune checkpoint molecule regulator which are to be concomitantly administered.
Inventors:
OHKUBO SHUICHI (JP)
Application Number:
PCT/JP2018/024776
Publication Date:
January 03, 2019
Filing Date:
June 29, 2018
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K31/437; A61K39/395; A61K45/00; A61P35/00; A61P37/04; A61P43/00; C07D471/04
Domestic Patent References:
| WO2015046498A1 | 2015-04-02 | |||
| WO2011004610A1 | 2011-01-13 | |||
| WO2016130502A1 | 2016-08-18 | |||
| WO2004004771A1 | 2004-01-15 | |||
| WO2011004610A1 | 2011-01-13 | |||
| WO2015046498A1 | 2015-04-02 |
Other References:
MALL, CHRISTINE ET AL.: "Repeated PD-1/PD-L1 monoclonal antibody administration induces fatal xenogeneic hypersensitivity reactions in a murine model of breast cancer", ONCOIMMUNOLOGY, vol. 5, no. 2, 2016, pages el075114/l - e1075114/12, XP055566284, ISSN: 2162-402X
MBOFUNG, M. RINA ET AL.: "Inhibition of HSP90 enhances T cell -mediated antitumor immune responses through expression of interferon-alpha response Genes", CANCER RESEARCH, vol. 76, no. 14, 2016, pages 4360, XP009518575, DOI: 10.1158/1538-7445.AM2016-4360
FABIO, DI ROMANO ET AL.: "Dihydropyrrole [2, 3-d] pyridine Derivatives as Novel Corticotropin-Releasing Factor-1 Antagonists: Mapping of the Receptor Binding Pocket by in Silico Docking Studies", J. MED. CHEM., vol. 51, 2008, pages 7273 - 7286, XP055043235, ISSN: 0022-2623
NAT. REV. CANCER, vol. 5, 2005, pages 761 - 772
TRENDS MOL. MED., vol. 10, 2004, pages 283 - 290
CLIN. CANCER RES., vol. 15, 2009, pages 9 - 14
CURR. OPIN. PHARMACOL., vol. 8, 2008, pages 370 - 374
DRUG RESIST. UPDAT., vol. 12, 2009, pages 17 - 27
NAT. REV. CANCER, vol. 12, 2012, pages 252 - 264
N. ENGL. J. MED., vol. 366, 2012, pages 2443 - 2454
NAT. REV. IMMUNOL., vol. 6, 2006, pages 343 - 357
See also references of EP 3646869A4
MBOFUNG, M. RINA ET AL.: "Inhibition of HSP90 enhances T cell -mediated antitumor immune responses through expression of interferon-alpha response Genes", CANCER RESEARCH, vol. 76, no. 14, 2016, pages 4360, XP009518575, DOI: 10.1158/1538-7445.AM2016-4360
FABIO, DI ROMANO ET AL.: "Dihydropyrrole [2, 3-d] pyridine Derivatives as Novel Corticotropin-Releasing Factor-1 Antagonists: Mapping of the Receptor Binding Pocket by in Silico Docking Studies", J. MED. CHEM., vol. 51, 2008, pages 7273 - 7286, XP055043235, ISSN: 0022-2623
NAT. REV. CANCER, vol. 5, 2005, pages 761 - 772
TRENDS MOL. MED., vol. 10, 2004, pages 283 - 290
CLIN. CANCER RES., vol. 15, 2009, pages 9 - 14
CURR. OPIN. PHARMACOL., vol. 8, 2008, pages 370 - 374
DRUG RESIST. UPDAT., vol. 12, 2009, pages 17 - 27
NAT. REV. CANCER, vol. 12, 2012, pages 252 - 264
N. ENGL. J. MED., vol. 366, 2012, pages 2443 - 2454
NAT. REV. IMMUNOL., vol. 6, 2006, pages 343 - 357
See also references of EP 3646869A4
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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