Title:
CHENODEOXYCHOLIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2016/173524
Kind Code:
A1
Abstract:
Disclosed in the present application are the compounds as shown in formulae I, II, III, IV or V, tautomers thereof, stereoisomers thereof or pharmaceutically acceptable salts thereof, and also disclosed is the use thereof in preparing drugs for treating FXR-related diseases.
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Inventors:
HE HAIYING (CN)
LI PENG (CN)
XIAO HUALING (CN)
CHEN ZHENGXIA (CN)
ZHANG YANG (CN)
CHEN SHUHUI (CN)
HU GUOPING (CN)
LI JIAN (CN)
LI PENG (CN)
XIAO HUALING (CN)
CHEN ZHENGXIA (CN)
ZHANG YANG (CN)
CHEN SHUHUI (CN)
HU GUOPING (CN)
LI JIAN (CN)
Application Number:
PCT/CN2016/080635
Publication Date:
November 03, 2016
Filing Date:
April 29, 2016
Export Citation:
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
MEDSHINE DISCOVERY INC (CN)
MEDSHINE DISCOVERY INC (CN)
International Classes:
C07J9/00; A61K31/575; A61K31/58; A61P43/00; C07J31/00; C07J33/00; C07J41/00; C07J43/00; C07J53/00; C07J71/00
Domestic Patent References:
| WO2016045480A1 | 2016-03-31 | |||
| WO2005082925A2 | 2005-09-09 | |||
| WO2016086115A1 | 2016-06-02 |
Foreign References:
| CN104672290A | 2015-06-03 | |||
| JP2013206716A | 2013-10-07 |
Other References:
PELLICCIARI, R. ET AL.: "Back Door Modulation of the Farnesoid X Receptor: Design, Synthesis, and Biological Evaluation of a Series of Side Chain Modified Chenodeoxycholic Acid Derivatives", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, no. 14, 15 June 2006 (2006-06-15), pages 4208 - 4215, XP008092111
PELLICCIARI, R. ET AL.: "Bile Acid Derivatives as Ligands of the Farnesoid X Receptor. Synthesis, Evaluation, and Structure-Activity Relationship of a Series of Body and Side Chain Modified Analogues of Chenodeoxycholic Acid", JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, no. 18, 23 July 2004 (2004-07-23), pages 4559 - 4569, XP002370634
BABU, P. ET AL.: "Micellar Aggregates and Hydrogels from Phosphonobile Salts", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 3, no. 20, 8 September 2005 (2005-09-08), pages 3695 - 3700, XP055230783
PELLICCIARI, R. ET AL.: "Bile Acid Derivatives as Ligands of the Farnesoid X Receptor. Synthesis, Evaluation, and Structure-Activity Relationship of a Series of Body and Side Chain Modified Analogues of Chenodeoxycholic Acid", JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, no. 18, 23 July 2004 (2004-07-23), pages 4559 - 4569, XP002370634
BABU, P. ET AL.: "Micellar Aggregates and Hydrogels from Phosphonobile Salts", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 3, no. 20, 8 September 2005 (2005-09-08), pages 3695 - 3700, XP055230783
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
上海弼兴律师事务所 (CN)
上海弼兴律师事务所 (CN)
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