Title:
ACTIVIN/BMP7 CHIMERAS: SUPER-ACTIVE SAB704 AND SAB715, AND THEIR RESPECTIVE NOGGIN-SENSITIZED VARIANTS, NAB704 AND NAB715; AND NAB204
Document Type and Number:
WIPO Patent Application WO/2020/101366
Kind Code:
A1
Abstract:
The present disclosure relates to chimeric polypeptide having TGF-beta activity, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides with improved or novel biological and therapeutic properties.
Inventors:
CHOE SEUNGHYON (KR)
YOON SO-MI (KR)
YOON SO-MI (KR)
Application Number:
PCT/KR2019/015478
Publication Date:
May 22, 2020
Filing Date:
November 13, 2019
Export Citation:
Assignee:
JOINT CENTER FOR BIOSCIENCES (KR)
International Classes:
C07K14/495; A61K38/00; C07K14/475; C07K14/51; C12N5/00
Domestic Patent References:
| WO2017209519A1 | 2017-12-07 | |||
| WO2008051526A2 | 2008-05-02 |
Foreign References:
| US20100221777A1 | 2010-09-02 |
Other References:
GEORGE P. ALLENDORPH, JESSICA D. READ, YASUHIKO KAWAKAMI, JONATHAN A. KELBER, MICHAEL J. ISAACS, SENYON CHOE: "Designer TGFβ Superfamily Ligands with Diversified Functionality", PLOS ONE, vol. 6, no. 11, pages e26402, XP055630590, DOI: 10.1371/journal.pone.0026402
BYUNG-HAK YOON, LUIS ESQUIVIES, CHIHOON AHN, PETER C GRAY, SANG-KYU YE, WITEK KWIATKOWSKI, SENYON CHOE: "An Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2 : BONE-HEALING PROPERTIES OF AN ACTIVIN A/BMP2 CHIMERA", JOURNAL OF BONE AND MINERAL RESEARCH, BLACKWELL SCIENCE, INC., US, vol. 29, no. 9, 1 September 2014 (2014-09-01), US, pages 1950 - 1959, XP055630032, ISSN: 0884-0431, DOI: 10.1002/jbmr.2238
MEEJUNG KIM, JONG IN KIM, JAE BUM KIM, SENYON CHOE: "The activin-βA/BMP-2 Chimera AB204 Is a Strong Stimulator of Adipogenesis", JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, JOHN WILEY & SONS, US, vol. 11, no. 5, 1 May 2017 (2017-05-01), US, pages 1524 - 1531, XP055707456, ISSN: 1932-6254, DOI: 10.1002/term.2050
See also references of EP 3880695A4
BYUNG-HAK YOON, LUIS ESQUIVIES, CHIHOON AHN, PETER C GRAY, SANG-KYU YE, WITEK KWIATKOWSKI, SENYON CHOE: "An Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2 : BONE-HEALING PROPERTIES OF AN ACTIVIN A/BMP2 CHIMERA", JOURNAL OF BONE AND MINERAL RESEARCH, BLACKWELL SCIENCE, INC., US, vol. 29, no. 9, 1 September 2014 (2014-09-01), US, pages 1950 - 1959, XP055630032, ISSN: 0884-0431, DOI: 10.1002/jbmr.2238
MEEJUNG KIM, JONG IN KIM, JAE BUM KIM, SENYON CHOE: "The activin-βA/BMP-2 Chimera AB204 Is a Strong Stimulator of Adipogenesis", JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, JOHN WILEY & SONS, US, vol. 11, no. 5, 1 May 2017 (2017-05-01), US, pages 1524 - 1531, XP055707456, ISSN: 1932-6254, DOI: 10.1002/term.2050
See also references of EP 3880695A4
Attorney, Agent or Firm:
YOON, Dae Woong (KR)
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