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Title:
CHIMERIC ANTIGEN RECEPTOR CELLS TARGETING ROBO1, PREPARATION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/218710
Kind Code:
A1
Abstract:
Provided are chimeric antigen receptor cells targeting ROBO1, in particular, enhanced CAR-T cells and CAR-NK cells targeting ROBO1, and preparation and application thereof. The cells can stably expressing CAR elements, while secreting extracellular domain molecules expressing PD-1 protein or mutants thereof, and thus may bloc PD-1/PD-L1 molecular interaction. It has been found through animal experiments that the cells have very good anti-tumor effects, and the above-mentioned cells can significantly reduce tumor recurrence and improve the survival rate compared with the conventional ROBO1-targeted CAR modified cells.

Inventors:
WANG BAOLEI (CN)
HAN KUNKUN (CN)
LI HUASHUN (CN)
Application Number:
PCT/CN2017/089517
Publication Date:
December 06, 2018
Filing Date:
June 22, 2017
Export Citation:
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Assignee:
ASCLEPIUS SUZHOU TECH COMPANY GROUP CO LTD (CN)
International Classes:
A61K38/17; C12N5/10; A61P35/00; C12N15/62; C12N15/867
Domestic Patent References:
WO2015142675A22015-09-24
Foreign References:
CN105907719A2016-08-31
CN106317228A2017-01-11
CN106399255A2017-02-15
CN105392888A2016-03-09
CN105132445A2015-12-09
CN104114233A2014-10-22
Other References:
QIU, HUI ET ET AL.: "Regulatory Effect of Secretory Recombinant Peptide PD-1- Cell I (P/C-1) on the Function of Immune Cells and its Anti-tumor Effect", CHINESE JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY, vol. 26, no. 12, 31 December 2006 (2006-12-31), pages 1054
Attorney, Agent or Firm:
BRIGHTHEAD INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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